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10.1016/j.jmb.2021.166945 http://scihub22266oqcxt.onion/10.1016/j.jmb.2021.166945 33753053!7979270!33753053     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Biol 2021 ; 433 (10): 166945 Nephropedia Template TP {{tp|p=33753053|t=2021. Platforms for Personalized Polytherapeutics Discovery in COVID-19 |pdf=|usr=}}{{33753053}} gab.com Text Platforms for Personalized Polytherapeutics Discovery in COVID-19 JO: J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=33753053 #FOAvip The COVID-19 pandemic entered its third and most intense to date wave of infections in November 2020. This perspective article describes how combination therapies (polytherapeutics) are a needed focus for helping battle the severity of complications from SARS-CoV-2 infection. It outlines the types of systems that are needed for fast and efficient combinatorial assessment of therapeutic candidates. Proposed are micro-physiological systems using human iPSC as a format for tissue-specific modeling of infection, the use of gene-humanized zebrafish and C. elegans for combinatorial drug screens due to the animals being addressable in liquid multi-well formats, and the use of engineered pseudo-typing systems to safely model infection in the transgenic animals and engineered tissue systems. Twit Text FOAVip Platforms for Personalized Polytherapeutics Discovery in COVID-19 ????J Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=33753053 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33753053 #FOAvip English Wikipedia <ref>{{Cite pmid|33753053}}</ref> Platforms for Personalized Polytherapeutics Discovery in COVID-19 #MMPMID33753053 Hopkins C; Onweni C; Zambito V; Fairweather D; McCormick K; Ebihara H; Caulfield T; Zhang YS; Freeman WD J Mol Biol 2021[May]; 433 (10): 166945 PMID33753053show ga The COVID-19 pandemic entered its third and most intense to date wave of infections in November 2020. This perspective article describes how combination therapies (polytherapeutics) are a needed focus for helping battle the severity of complications from SARS-CoV-2 infection. It outlines the types of systems that are needed for fast and efficient combinatorial assessment of therapeutic candidates. Proposed are micro-physiological systems using human iPSC as a format for tissue-specific modeling of infection, the use of gene-humanized zebrafish and C. elegans for combinatorial drug screens due to the animals being addressable in liquid multi-well formats, and the use of engineered pseudo-typing systems to safely model infection in the transgenic animals and engineered tissue systems. |*COVID-19 Drug Treatment[MESH] |*Disease Models, Animal[MESH] |Animals[MESH] |Animals, Genetically Modified[MESH] |COVID-19/economics/genetics[MESH] |Caenorhabditis elegans/drug effects/genetics[MESH] |Drug Evaluation, Preclinical/*methods[MESH] |Humans[MESH] |Induced Pluripotent Stem Cells/*drug effects[MESH]Platforms for Personalized Polytherapeutics Discovery in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing