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10.1002/bies.202000325 http://scihub22266oqcxt.onion/10.1002/bies.202000325 33751609!8250263!33751609     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioessays 2021 ; 43 (5): e2000325 Nephropedia Template TP {{tp|p=33751609|t=2021. There is no evidence of SARS-CoV-2 laboratory origin: Response to Segreto and Deigin (DOI: 10 1002/bies 202000240) |pdf=|usr=}}{{33751609}} gab.com Text There is no evidence of SARS-CoV-2 laboratory origin: Response to Segreto and Deigin (DOI: 10 1002/bies 202000240) JO: Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=33751609 #FOAvip The origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the subject of many hypotheses. One of them, proposed by Segreto and Deigin, assumes artificial chimeric construction of SARS-CoV-2 from a backbone of RaTG13-like CoV and receptor binding domain (RBD) of a pangolin MP789-like CoV, followed by serial cell or animal passage. Here we show that this hypothesis relies on incorrect or weak assumptions, and does not agree with the results of comparative genomics analysis. The genetic divergence between SARS-CoV-2 and both its proposed ancestors is too high to have accumulated in a lab, given the timeframe of several years. Furthermore, comparative analysis of S-protein gene sequences suggests that the RBD of SARS-CoV-2 probably represents an ancestral non-recombinant variant. These and other arguments significantly weaken the hypothesis of a laboratory origin for SARS-CoV-2, while the hypothesis of a natural origin is consistent with all available genetic and experimental data. Twit Text FOAVip There is no evidence of SARS-CoV-2 laboratory origin: Response to Segreto and Deigin (DOI: 10 1002/bies 202000240) ????Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=33751609 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33751609 #FOAvip English Wikipedia <ref>{{Cite pmid|33751609}}</ref> There is no evidence of SARS-CoV-2 laboratory origin: Response to Segreto and Deigin (DOI: 10 1002/bies 202000240) #MMPMID33751609 Tyshkovskiy A; Panchin AY Bioessays 2021[May]; 43 (5): e2000325 PMID33751609show ga The origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the subject of many hypotheses. One of them, proposed by Segreto and Deigin, assumes artificial chimeric construction of SARS-CoV-2 from a backbone of RaTG13-like CoV and receptor binding domain (RBD) of a pangolin MP789-like CoV, followed by serial cell or animal passage. Here we show that this hypothesis relies on incorrect or weak assumptions, and does not agree with the results of comparative genomics analysis. The genetic divergence between SARS-CoV-2 and both its proposed ancestors is too high to have accumulated in a lab, given the timeframe of several years. Furthermore, comparative analysis of S-protein gene sequences suggests that the RBD of SARS-CoV-2 probably represents an ancestral non-recombinant variant. These and other arguments significantly weaken the hypothesis of a laboratory origin for SARS-CoV-2, while the hypothesis of a natural origin is consistent with all available genetic and experimental data. |*COVID-19[MESH] |*Chiroptera[MESH] |Animals[MESH] |Humans[MESH] |Laboratories[MESH] |SARS-CoV-2[MESH]There is no evidence of SARS-CoV-2 laboratory origin: Response to Segr(epmc).pdf DeepDyve Pubget Overpricing