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10.1111/bph.15432 http://scihub22266oqcxt.onion/10.1111/bph.15432 33751579!8432553!33751579     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33751579&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Br+J+Pharmacol 2021 ; 178 (12): 2375-2392 Nephropedia Template TP {{tp|p=33751579|t=2021. Clinical applications for exosomes: Are we there yet?|pdf=|usr=}}{{33751579}} gab.com Text Clinical applications for exosomes: Are we there yet JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33751579 #FOAvip Exosomes are a subset of extracellular vesicles essential for cell-cell communication in health and disease with the ability to transport nucleic acids, functional proteins and other metabolites. Their clinical use as diagnostic biomarkers and therapeutic carriers has become a major field of research over recent years, generating rapidly expanding scientific interest and financial investment. Their reduced immunogenicity compared to liposomes or viral vectors and their ability to cross major physiological barriers like the blood-brain barrier make them an appealing and innovative option as biomarkers and therapeutic agents. Here, we review the latest clinical developments of exosome biotechnology for diagnostic and therapeutic purposes, including the most recent COVID-19-related exosome-based clinical trials. We present current exosome engineering strategies for optimal clinical safety and efficacy, and assess the technology developed for good manufacturing practice compliant scaling up and storage approaches along with their limitations in pharmaceutical industry. Twit Text FOAVip Clinical applications for exosomes: Are we there yet ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33751579 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33751579 #FOAvip English Wikipedia <ref>{{Cite pmid|33751579}}</ref> Clinical applications for exosomes: Are we there yet? #MMPMID33751579 Perocheau D; Touramanidou L; Gurung S; Gissen P; Baruteau J Br J Pharmacol 2021[Jun]; 178 (12): 2375-2392 PMID33751579show ga Exosomes are a subset of extracellular vesicles essential for cell-cell communication in health and disease with the ability to transport nucleic acids, functional proteins and other metabolites. Their clinical use as diagnostic biomarkers and therapeutic carriers has become a major field of research over recent years, generating rapidly expanding scientific interest and financial investment. Their reduced immunogenicity compared to liposomes or viral vectors and their ability to cross major physiological barriers like the blood-brain barrier make them an appealing and innovative option as biomarkers and therapeutic agents. Here, we review the latest clinical developments of exosome biotechnology for diagnostic and therapeutic purposes, including the most recent COVID-19-related exosome-based clinical trials. We present current exosome engineering strategies for optimal clinical safety and efficacy, and assess the technology developed for good manufacturing practice compliant scaling up and storage approaches along with their limitations in pharmaceutical industry. |*COVID-19[MESH] |*Exosomes[MESH] |*Extracellular Vesicles[MESH] |Drug Delivery Systems[MESH] |Humans[MESH]Clinical applications for exosomes: Are we there yet?(epmc).pdf DeepDyve Pubget Overpricing