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10.1093/jmcb/mjab014

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33751111!7989217!33751111
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suck abstract from ncbi


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pmid33751111      J+Mol+Cell+Biol 2021 ; 13 (3): 197-209
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  • Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19 #MMPMID33751111
  • Yang J; Zhong M; Zhang E; Hong K; Yang Q; Zhou D; Xia J; Chen YQ; Sun M; Zhao B; Xiang J; Liu Y; Han Y; Xu M; Zhou X; Huang C; Shang Y; Yan H
  • J Mol Cell Biol 2021[Jul]; 13 (3): 197-209 PMID33751111show ga
  • Although millions of patients have clinically recovered from COVID-19, little is known about the immune status of lymphocytes in these individuals. In this study, the peripheral blood mononuclear cells of a clinically recovered (CR) cohort were comparatively analyzed with those of an age- and sex-matched healthy donor cohort. We found that CD8+ T cells in the CR cohort had higher numbers of effector T cells and effector memory T cells but lower Tc1 (IFN-gamma+), Tc2 (IL-4+), and Tc17 (IL-17A+) cell frequencies. The CD4+ T cells of the CR cohort were decreased in frequency, especially the central memory T cell subset. Moreover, CD4+ T cells in the CR cohort showed lower programmed cell death protein 1 (PD-1) expression and had lower frequencies of Th1 (IFN-gamma+), Th2 (IL-4+), Th17 (IL-17A+), and circulating follicular helper T (CXCR5+PD-1+) cells. Accordingly, the proportion of isotype-switched memory B cells (IgM-CD20hi) among B cells in the CR cohort showed a significantly lower proportion, although the level of the activation marker CD71 was elevated. For CD3-HLA-DR- lymphocytes in the CR cohort, in addition to lower levels of IFN-gamma, granzyme B and T-bet, the correlation between T-bet and IFN-gamma was not observed. Additionally, by taking into account the number of days after discharge, all the phenotypes associated with reduced function did not show a tendency toward recovery within 4?11 weeks. The remarkable phenotypic alterations in lymphocytes in the CR cohort suggest that severe acute respiratory syndrome coronavirus 2 infection profoundly affects lymphocytes and potentially results in dysfunction even after clinical recovery.
  • |Adult[MESH]
  • |Aged[MESH]
  • |CD8-Positive T-Lymphocytes/immunology/pathology/*virology[MESH]
  • |COVID-19/*blood/epidemiology/pathology/virology[MESH]
  • |Cell Lineage/genetics/immunology[MESH]
  • |Female[MESH]
  • |Gene Expression Regulation/immunology[MESH]
  • |Granzymes/genetics[MESH]
  • |Humans[MESH]
  • |Interferon-gamma/genetics[MESH]
  • |Leukocytes, Mononuclear/pathology/*virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/*pathogenicity[MESH]
  • |T-Box Domain Proteins/genetics[MESH]
  • |Th1 Cells/immunology/virology[MESH]
  • |Th17 Cells/immunology/virology[MESH]


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