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10.1371/journal.pone.0248918 http://scihub22266oqcxt.onion/10.1371/journal.pone.0248918 33750984!7984607!33750984     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (3): e0248918 Nephropedia Template TP {{tp|p=33750984|t=2021. Antibody kinetics and clinical course of COVID-19 a prospective observational study |pdf=|usr=}}{{33750984}} gab.com Text Antibody kinetics and clinical course of COVID-19 a prospective observational study JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33750984 #FOAvip BACKGROUND: Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. MATERIALS AND METHODS: A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. RESULTS: Forty patients with COVID-19, hospitalized at Skane University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV-2 spike protein compared with patients with mild disease. CONCLUSION: IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels. Twit Text FOAVip Antibody kinetics and clinical course of COVID-19 a prospective observational study ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33750984 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33750984 #FOAvip English Wikipedia <ref>{{Cite pmid|33750984}}</ref> Antibody kinetics and clinical course of COVID-19 a prospective observational study #MMPMID33750984 Blackberg A; Fernstrom N; Sarbrant E; Rasmussen M; Sunnerhagen T PLoS One 2021[]; 16 (3): e0248918 PMID33750984show ga BACKGROUND: Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. MATERIALS AND METHODS: A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. RESULTS: Forty patients with COVID-19, hospitalized at Skane University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV-2 spike protein compared with patients with mild disease. CONCLUSION: IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels. |Aged[MESH] |Antibodies, Viral/*blood[MESH] |Antibody Formation[MESH] |COVID-19/*pathology/virology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin A/blood[MESH] |Immunoglobulin G/blood[MESH] |Kinetics[MESH] |Male[MESH] |Middle Aged[MESH] |Prospective Studies[MESH] |SARS-CoV-2/isolation & purification[MESH] |Severity of Illness Index[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH]Antibody kinetics and clinical course of COVID-19 a prospective observ(epmc).pdf DeepDyve Pubget Overpricing