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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Commun 2021 ; 12 (1): 1533 Nephropedia Template TP
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Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China #MMPMID33750783
Hu S; Wang W; Wang Y; Litvinova M; Luo K; Ren L; Sun Q; Chen X; Zeng G; Li J; Liang L; Deng Z; Zheng W; Li M; Yang H; Guo J; Wang K; Chen X; Liu Z; Yan H; Shi H; Chen Z; Zhou Y; Sun K; Vespignani A; Viboud C; Gao L; Ajelli M; Yu H
Nat Commun 2021[Mar]; 12 (1): 1533 PMID33750783show ga
Several mechanisms driving SARS-CoV-2 transmission remain unclear. Based on individual records of 1178 potential SARS-CoV-2 infectors and their 15,648 contacts in Hunan, China, we estimated key transmission parameters. The mean generation time was estimated to be 5.7 (median: 5.5, IQR: 4.5, 6.8) days, with infectiousness peaking 1.8 days before symptom onset, with 95% of transmission events occurring between 8.8 days before and 9.5 days after symptom onset. Most transmission events occurred during the pre-symptomatic phase (59.2%). SARS-CoV-2 susceptibility to infection increases with age, while transmissibility is not significantly different between age groups and between symptomatic and asymptomatic individuals. Contacts in households and exposure to first-generation cases are associated with higher odds of transmission. Our findings support the hypothesis that children can effectively transmit SARS-CoV-2 and highlight how pre-symptomatic and asymptomatic transmission can hinder control efforts.