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10.15252/msb.20209923 http://scihub22266oqcxt.onion/10.15252/msb.20209923 33749993!7983032!33749993     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Syst+Biol 2021 ; 17 (3): e9923 Nephropedia Template TP {{tp|p=33749993|t=2021. Integrated intra- and intercellular signaling knowledge for multicellular omics analysis |pdf=|usr=}}{{33749993}} gab.com Text Integrated intra- and intercellular signaling knowledge for multicellular omics analysis JO: Mol Syst Biol http://www.kidney.de/pget.php?&tw=1&pmid=33749993 #FOAvip Molecular knowledge of biological processes is a cornerstone in omics data analysis. Applied to single-cell data, such analyses provide mechanistic insights into individual cells and their interactions. However, knowledge of intercellular communication is scarce, scattered across resources, and not linked to intracellular processes. To address this gap, we combined over 100 resources covering interactions and roles of proteins in inter- and intracellular signaling, as well as transcriptional and post-transcriptional regulation. We added protein complex information and annotations on function, localization, and role in diseases for each protein. The resource is available for human, and via homology translation for mouse and rat. The data are accessible via OmniPath's web service (https://omnipathdb.org/), a Cytoscape plug-in, and packages in R/Bioconductor and Python, providing access options for computational and experimental scientists. We created workflows with tutorials to facilitate the analysis of cell-cell interactions and affected downstream intracellular signaling processes. OmniPath provides a single access point to knowledge spanning intra- and intercellular processes for data analysis, as we demonstrate in applications studying SARS-CoV-2 infection and ulcerative colitis. Twit Text FOAVip Integrated intra- and intercellular signaling knowledge for multicellular omics analysis ????Mol Syst Biol http://www.kidney.de/pget.php?&tw=1&pmid=33749993 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33749993 #FOAvip English Wikipedia <ref>{{Cite pmid|33749993}}</ref> Integrated intra- and intercellular signaling knowledge for multicellular omics analysis #MMPMID33749993 Turei D; Valdeolivas A; Gul L; Palacio-Escat N; Klein M; Ivanova O; Olbei M; Gabor A; Theis F; Modos D; Korcsmaros T; Saez-Rodriguez J Mol Syst Biol 2021[Mar]; 17 (3): e9923 PMID33749993show ga Molecular knowledge of biological processes is a cornerstone in omics data analysis. Applied to single-cell data, such analyses provide mechanistic insights into individual cells and their interactions. However, knowledge of intercellular communication is scarce, scattered across resources, and not linked to intracellular processes. To address this gap, we combined over 100 resources covering interactions and roles of proteins in inter- and intracellular signaling, as well as transcriptional and post-transcriptional regulation. We added protein complex information and annotations on function, localization, and role in diseases for each protein. The resource is available for human, and via homology translation for mouse and rat. The data are accessible via OmniPath's web service (https://omnipathdb.org/), a Cytoscape plug-in, and packages in R/Bioconductor and Python, providing access options for computational and experimental scientists. We created workflows with tutorials to facilitate the analysis of cell-cell interactions and affected downstream intracellular signaling processes. OmniPath provides a single access point to knowledge spanning intra- and intercellular processes for data analysis, as we demonstrate in applications studying SARS-CoV-2 infection and ulcerative colitis. |*Signal Transduction[MESH] |Animals[MESH] |COVID-19/*metabolism[MESH] |Cell Communication[MESH] |Colitis, Ulcerative/*metabolism/pathology[MESH] |Computational Biology/*methods[MESH] |Databases, Factual[MESH] |Enzymes/metabolism[MESH] |Humans[MESH] |Mice[MESH] |Protein Processing, Post-Translational[MESH] |Proteins/genetics/*metabolism[MESH] |Rats[MESH] |Single-Cell Analysis[MESH] |Software[MESH]Integrated intra- and intercellular signaling knowledge for multicellu(epmc).pdf DeepDyve Pubget Overpricing