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10.1172/jci.insight.144350 http://scihub22266oqcxt.onion/10.1172/jci.insight.144350 33749660!8026189!33749660     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2021 ; 6 (6): ä Nephropedia Template TP {{tp|p=33749660|t=2021. Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore-Washington metropolitan area |pdf=|usr=}}{{33749660}} gab.com Text Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore-Washington metropolitan area JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33749660 #FOAvip The early COVID-19 pandemic was characterized by rapid global spread. In Maryland and Washington, DC, United States, more than 2500 cases were reported within 3 weeks of the first COVID-19 detection in March 2020. We aimed to use genomic sequencing to understand the initial spread of SARS-CoV-2 - the virus that causes COVID-19 - in the region. We analyzed 620 samples collected from the Johns Hopkins Health System during March 11-31, 2020, comprising 28.6% of the total cases in Maryland and Washington, DC. From these samples, we generated 114 complete viral genomes. Analysis of these genomes alongside a subsampling of over 1000 previously published sequences showed that the diversity in this region rivaled global SARS-CoV-2 genetic diversity at that time and that the sequences belong to all of the major globally circulating lineages, suggesting multiple introductions into the region. We also analyzed these regional SARS-CoV-2 genomes alongside detailed clinical metadata and found that clinically severe cases had viral genomes belonging to all major viral lineages. We conclude that efforts to control local spread of the virus were likely confounded by the number of introductions into the region early in the epidemic and the interconnectedness of the region as a whole. Twit Text FOAVip Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore-Washington metropolitan area ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=33749660 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33749660 #FOAvip English Wikipedia <ref>{{Cite pmid|33749660}}</ref> Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore-Washington metropolitan area #MMPMID33749660 Thielen PM; Wohl S; Mehoke T; Ramakrishnan S; Kirsche M; Falade-Nwulia O; Trovao NS; Ernlund A; Howser C; Sadowski N; Morris CP; Hopkins M; Schwartz M; Fan Y; Gniazdowski V; Lessler J; Sauer L; Schatz MC; Evans JD; Ray SC; Timp W; Mostafa HH JCI Insight 2021[Mar]; 6 (6): ä PMID33749660show ga The early COVID-19 pandemic was characterized by rapid global spread. In Maryland and Washington, DC, United States, more than 2500 cases were reported within 3 weeks of the first COVID-19 detection in March 2020. We aimed to use genomic sequencing to understand the initial spread of SARS-CoV-2 - the virus that causes COVID-19 - in the region. We analyzed 620 samples collected from the Johns Hopkins Health System during March 11-31, 2020, comprising 28.6% of the total cases in Maryland and Washington, DC. From these samples, we generated 114 complete viral genomes. Analysis of these genomes alongside a subsampling of over 1000 previously published sequences showed that the diversity in this region rivaled global SARS-CoV-2 genetic diversity at that time and that the sequences belong to all of the major globally circulating lineages, suggesting multiple introductions into the region. We also analyzed these regional SARS-CoV-2 genomes alongside detailed clinical metadata and found that clinically severe cases had viral genomes belonging to all major viral lineages. We conclude that efforts to control local spread of the virus were likely confounded by the number of introductions into the region early in the epidemic and the interconnectedness of the region as a whole. |*Genome, Viral[MESH] |*Pandemics[MESH] |*Phylogeny[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Baltimore[MESH] |Base Sequence[MESH] |COVID-19/epidemiology/transmission/*virology[MESH] |Child[MESH] |Disease Outbreaks[MESH] |Disease Transmission, Infectious[MESH] |District of Columbia[MESH] |Female[MESH] |Genomics/methods[MESH] |Global Health[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*genetics[MESH]Genomic diversity of SARS-CoV-2 during early introduction into the Ba(epmc).pdf DeepDyve Pubget Overpricing