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  • Aspectos microbiologicos actuales de la infeccion respiratoria comunitaria mas alla de la COVID-19 #MMPMID33749214
  • Canton R
  • Rev Esp Quimioter 2021[Apr]; 34 (2): 81-92 PMID33749214show ga
  • From a microbiological point of view, both empirical and targeted antimicrobial treatment in respiratory infection is based on the sensitivity profile of isolated microorganisms and the possible resistance mechanisms that they may present. The latter may vary in different geographic areas according to prescription profiles and vaccination programs. Beta-lactam antibiotics, fluoroquinolones, and macrolides are the most commonly used antimicrobials during the exacerbations of chronic obstructive pulmonary disease and community-acquired pneumonia. In their prescription, different aspects such as intrinsic activity, bactericidal effect or their ability to prevent the development of resistance must be taken into account. The latter is related to the PK/PD parameters, the mutant prevention concentration and the so-called selection window. More recently, the potential ecological impact has grown in importance, not only on the intestinal microbiota, but also on the respiratory one. Maintaining the state of eubiosis requires the use of antimicrobials with a low profile of action on anaerobic bacteria. With their use, the resilience of the bacterial populations belonging to the microbiota, the state of resistance of colonization and the collateral damage related to the emergence of resistance to the antimicrobials in pathogens causing the infections and in the bacterial populations integrating the microbiota.
  • |*Drug Resistance, Bacterial[MESH]
  • |Administration, Oral[MESH]
  • |Anti-Bacterial Agents/administration & dosage/*pharmacology[MESH]
  • |COVID-19/*epidemiology[MESH]
  • |Chlamydophila pneumoniae/drug effects[MESH]
  • |Community-Acquired Infections/drug therapy/microbiology[MESH]
  • |Disease Progression[MESH]
  • |Gastrointestinal Microbiome/drug effects[MESH]
  • |Haemophilus influenzae/drug effects[MESH]
  • |Humans[MESH]
  • |Microbial Sensitivity Tests[MESH]
  • |Moraxella catarrhalis/drug effects[MESH]
  • |Mycoplasma pneumoniae/drug effects[MESH]
  • |Pseudomonas aeruginosa/drug effects[MESH]
  • |Pulmonary Disease, Chronic Obstructive/*drug therapy/microbiology[MESH]
  • |Respiratory Tract Infections/*drug therapy/microbiology[MESH]
  • |Staphylococcus aureus/drug effects[MESH]
  • |Streptococcus pneumoniae/drug effects[MESH]

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  • suck abstract from ncbi

    81 2.34 2021