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10.1016/j.xcrm.2021.100229

http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100229
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suck abstract from ncbi


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pmid33748789      Cell+Rep+Med 2021 ; 2 (4): 100229
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  • Bacterial pulmonary superinfections are associated with longer duration of ventilation in critically ill COVID-19 patients #MMPMID33748789
  • Buehler PK; Zinkernagel AS; Hofmaenner DA; Wendel Garcia PD; Acevedo CT; Gomez-Mejia A; Mairpady Shambat S; Andreoni F; Maibach MA; Bartussek J; Hilty MP; Frey PM; Schuepbach RA; Brugger SD
  • Cell Rep Med 2021[Apr]; 2 (4): 100229 PMID33748789show ga
  • The impact of secondary bacterial infections (superinfections) in coronavirus disease 2019 (COVID-19) is not well understood. In this prospective, monocentric cohort study, we aim to investigate the impact of superinfections in COVID-19 patients with acute respiratory distress syndrome. Patients are assessed for concomitant microbial infections by longitudinal analysis of tracheobronchial secretions, bronchoalveolar lavages, and blood cultures. In 45 critically ill patients, we identify 19 patients with superinfections (42.2%). Superinfections are detected on day 10 after intensive care admission. The proportion of participants alive and off invasive mechanical ventilation at study day 28 (ventilator-free days [VFDs] at 28 days) is substantially lower in patients with superinfection (subhazard ratio 0.37; 95% confidence interval [CI] 0.15-0.90; p = 0.028). Patients with pulmonary superinfections have a higher incidence of bacteremia, virus reactivations, yeast colonization, and required intensive care treatment for a longer time. Superinfections are frequent and associated with reduced VFDs at 28 days despite a high rate of empirical antibiotic therapy.
  • |*Respiration, Artificial[MESH]
  • |Aged[MESH]
  • |Bronchoalveolar Lavage Fluid/microbiology[MESH]
  • |COVID-19/complications/*pathology/virology[MESH]
  • |Cohort Studies[MESH]
  • |Critical Illness[MESH]
  • |Enterococcus faecalis/isolation & purification[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Intensive Care Units[MESH]
  • |Length of Stay[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pseudomonas aeruginosa/isolation & purification[MESH]
  • |SARS-CoV-2/isolation & purification[MESH]
  • |Superinfection/complications/*diagnosis/epidemiology[MESH]


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