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10.1016/j.isci.2021.102322 http://scihub22266oqcxt.onion/10.1016/j.isci.2021.102322 33748697!7968217!33748697     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2021 ; 24 (4): 102322 Nephropedia Template TP {{tp|p=33748697|t=2021. Common variants at 21q22 3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19 |pdf=|usr=}}{{33748697}} gab.com Text Common variants at 21q22 3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19 JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=33748697 #FOAvip The established risk factors of coronavirus disease 2019 (COVID-19) are advanced age, male sex, and comorbidities, but they do not fully explain the wide spectrum of disease manifestations. Genetic factors implicated in the host antiviral response provide for novel insights into its pathogenesis. We performed an in-depth genetic analysis of chromosome 21 exploiting the genome-wide association study data, including 6,406 individuals hospitalized for COVID-19 and 902,088 controls with European genetic ancestry from the COVID-19 Host Genetics Initiative. We found that five single nucleotide polymorphisms within TMPRSS2 and near MX1 gene show associations with severe COVID-19. The minor alleles of the five single nucleotide polymorphisms (SNPs) correlated with a reduced risk of developing severe COVID-19 and high level of MX1 expression in blood. Our findings demonstrate that host genetic factors can influence the different clinical presentations of COVID-19 and that MX1 could be a potential therapeutic target. Twit Text FOAVip Common variants at 21q22 3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19 ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=33748697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33748697 #FOAvip English Wikipedia <ref>{{Cite pmid|33748697}}</ref> Common variants at 21q22 3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19 #MMPMID33748697 Andolfo I; Russo R; Lasorsa VA; Cantalupo S; Rosato BE; Bonfiglio F; Frisso G; Abete P; Cassese GM; Servillo G; Esposito G; Gentile I; Piscopo C; Villani R; Fiorentino G; Cerino P; Buonerba C; Pierri B; Zollo M; Iolascon A; Capasso M iScience 2021[Apr]; 24 (4): 102322 PMID33748697show ga The established risk factors of coronavirus disease 2019 (COVID-19) are advanced age, male sex, and comorbidities, but they do not fully explain the wide spectrum of disease manifestations. Genetic factors implicated in the host antiviral response provide for novel insights into its pathogenesis. We performed an in-depth genetic analysis of chromosome 21 exploiting the genome-wide association study data, including 6,406 individuals hospitalized for COVID-19 and 902,088 controls with European genetic ancestry from the COVID-19 Host Genetics Initiative. We found that five single nucleotide polymorphisms within TMPRSS2 and near MX1 gene show associations with severe COVID-19. The minor alleles of the five single nucleotide polymorphisms (SNPs) correlated with a reduced risk of developing severe COVID-19 and high level of MX1 expression in blood. Our findings demonstrate that host genetic factors can influence the different clinical presentations of COVID-19 and that MX1 could be a potential therapeutic target. äCommon variants at 21q22 3 locus influence MX1 and TMPRSS2 gene expres(epmc).pdf DeepDyve Pubget Overpricing