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10.3389/fimmu.2021.602130 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.602130 33746948!7966717!33746948     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 602130 Nephropedia Template TP {{tp|p=33746948|t=2021. Lung Protection vs Infection Resolution: Interleukin 10 Suspected of Double-Dealing in COVID-19 |pdf=|usr=}}{{33746948}} gab.com Text Lung Protection vs Infection Resolution: Interleukin 10 Suspected of Double-Dealing in COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33746948 #FOAvip The pathological processes by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that make the virus a major threat to global health are insufficiently understood. Inefficient viral clearance at any stage is a hallmark of coronavirus disease 2019 (COVID-19). Disease severity is associated with increases in peripheral blood cytokines among which interleukin 10 (IL-10) increases particularly early and independent of patient age, which is not seen in active SARS-CoV infection. Here, we consider the known multi-faceted immune regulatory role of IL-10, both in protecting the lung from injury and in defense against infections, as well as its potential cellular source. While the absence of an IL-10 response in SARS is thought to contribute to early deterioration, we suspect IL-10 to protect the lung from early immune-mediated damage and to interfere with viral clearance in COVID-19. This may further both viral spread and poor outcome in many high-risk patients. Identifying the features of the viral genotype, which specifically underlie the different IL-10 dynamics as an etiological endotype and the different viral load kinetics and outcomes as clinical phenotype, may unveil a new immune evasive strategy of SARS-CoV-2. Twit Text FOAVip Lung Protection vs Infection Resolution: Interleukin 10 Suspected of Double-Dealing in COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33746948 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33746948 #FOAvip English Wikipedia <ref>{{Cite pmid|33746948}}</ref> Lung Protection vs Infection Resolution: Interleukin 10 Suspected of Double-Dealing in COVID-19 #MMPMID33746948 Lindner HA; Velasquez SY; Thiel M; Kirschning T Front Immunol 2021[]; 12 (ä): 602130 PMID33746948show ga The pathological processes by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that make the virus a major threat to global health are insufficiently understood. Inefficient viral clearance at any stage is a hallmark of coronavirus disease 2019 (COVID-19). Disease severity is associated with increases in peripheral blood cytokines among which interleukin 10 (IL-10) increases particularly early and independent of patient age, which is not seen in active SARS-CoV infection. Here, we consider the known multi-faceted immune regulatory role of IL-10, both in protecting the lung from injury and in defense against infections, as well as its potential cellular source. While the absence of an IL-10 response in SARS is thought to contribute to early deterioration, we suspect IL-10 to protect the lung from early immune-mediated damage and to interfere with viral clearance in COVID-19. This may further both viral spread and poor outcome in many high-risk patients. Identifying the features of the viral genotype, which specifically underlie the different IL-10 dynamics as an etiological endotype and the different viral load kinetics and outcomes as clinical phenotype, may unveil a new immune evasive strategy of SARS-CoV-2. |*Severity of Illness Index[MESH] |Adult[MESH] |Animals[MESH] |COVID-19 Vaccines/immunology[MESH] |COVID-19/*blood/*immunology/transmission/virology[MESH] |Child[MESH] |Genotype[MESH] |Humans[MESH] |Interleukin-10/*blood[MESH] |Lung/*immunology/*pathology[MESH] |Mice[MESH] |Phenotype[MESH] |SARS-CoV-2/*genetics/immunology[MESH]Lung Protection vs Infection Resolution: Interleukin 10 Suspected of (epmc).pdf DeepDyve Pubget Overpricing