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10.4014/jmb.2009.09029

http://scihub22266oqcxt.onion/10.4014/jmb.2009.09029
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33746189!9705840!33746189
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suck abstract from ncbi


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pmid33746189      J+Microbiol+Biotechnol 2021 ; 31 (3): 380-386
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  • Clinical Effect of Traditional Chinese Medicine Shenhuang Granule in Critically Ill Patients with COVID-19: A Single-Centered, Retrospective, Observational Study #MMPMID33746189
  • Feng J; Fang B; Zhou D; Wang J; Zou D; Yu G; Fen Y; Peng D; Hu J; Zhan D
  • J Microbiol Biotechnol 2021[Mar]; 31 (3): 380-386 PMID33746189show ga
  • The coronavirus disease 2019 (COVID-19) pandemic has become a public health emergency of global concern. In China, traditional Chinese medicine has been widely administered to COVID-19 patients without sufficient evidence. To evaluate the efficacy of Shenhuang Granule (SHG) for treating critically ill patients with COVID-19, we included in this study 118 patients who were admitted to the ICU of Tongji Hospital between January 28, 2020 and March 28, 2020. Among these patients, 33 (27.9%) received standard care plus SHG (treatment group) and 85 (72.1%) received standard care alone (control group). Enrolled patients had a median (IQR) age of 68 (57-75) years, and most (79 [67.1%]) were men. At end point of this study, 83 (70.3%) had died in ICU, 29 (24.5%) had been discharged from ICU, and 6 patients (5.2%) were still in ICU. Compared with control group, mortality was significantly lower in treatment group (45.4% vs. 80%, p < .001). Patients in treatment group were less likely to develop acute respiratory distress syndrome (ARDS) (12 [36.3%] vs. 54 [63.5%], p = 0.012) and cardiac injury (5 [15.1%] vs. 32 [37.6%], p = 0.026), and less likely to receive mechanical ventilation (22 [66.7%] vs. 72 [84.7%], p = 0.028) than those in control group. The median time from ICU admission to discharge was shorter in treatment group (32 [20-73] days vs. 76 [63-79] days, p = 0.0074). These findings suggest that SHG treatment as a complementary therapy might be effective for critically ill adults with COVID-19 and warrant further clinical trials.
  • |*COVID-19 Drug Treatment[MESH]
  • |Aged[MESH]
  • |China[MESH]
  • |Critical Illness[MESH]
  • |Drugs, Chinese Herbal/*therapeutic use[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Medicine, Chinese Traditional/methods[MESH]
  • |Middle Aged[MESH]
  • |Pandemics/prevention & control[MESH]


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