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10.1016/j.ijid.2021.03.051

http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.03.051
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33746093!7970753!33746093
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suck abstract from ncbi


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pmid33746093      Int+J+Infect+Dis 2021 ; 106 (ä): 8-12
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  • Analytical performances of the point-of-care SIENNA COVID-19 Antigen Rapid Test for the detection of SARS-CoV-2 nucleocapsid protein in nasopharyngeal swabs: A prospective evaluation during the COVID-19 second wave in France #MMPMID33746093
  • Mboumba Bouassa RS; Veyer D; Pere H; Belec L
  • Int J Infect Dis 2021[May]; 106 (ä): 8-12 PMID33746093show ga
  • OBJECTIVES: We herein assessed the analytical performances of the antigen-rapid diagnostic test (Ag-RDT) SIENNA COVID-19 Antigen Rapid Test Cassette (Nasopharyngeal Swab) (Salofa Oy, Salo, Finland), targeting the SARS-CoV-2 N nucleocapsid protein, for the diagnosis of COVID-19 in hospitalized patients with suspected SARS-CoV-2 infection, by reference to real-time RT-PCR (rRT-PCR). METHODS: Nasopharyngeal swabs were collected from patients with COVID-19-like illness during the second epidemic wave in Paris, France, among which 100 and 50 were positive and negative for SARS-CoV-2 RNA, respectively. RESULTS: Overall, the Ag-RDT showed high sensitivity, specificity, positive and negative predictive values of 90.0%, 100.0%, 100.0% and 98.1%, respectively, as well as high or almost perfect agreement (93.3%), reliability assessed by Cohen's kappa coefficient (0.86), and accuracy assessed by Youden's J index (90%) to detect SARS-CoV-2. The analytical performances of the Ag-RDT remained high in the event of significant viral excretion (i.e., N gene C(t) values 33). CONCLUSIONS: The SIENNA Ag-RDT presents excellent analytical performances for viral loads
  • |*Point-of-Care Testing[MESH]
  • |Adult[MESH]
  • |Antigens, Viral/*analysis[MESH]
  • |COVID-19 Testing/*methods[MESH]
  • |COVID-19/*diagnosis/epidemiology[MESH]
  • |France/epidemiology[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Nasopharynx/*virology[MESH]
  • |Nucleocapsid Proteins/*analysis[MESH]
  • |Predictive Value of Tests[MESH]
  • |Prospective Studies[MESH]
  • |Reproducibility of Results[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Sensitivity and Specificity[MESH]


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