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10.1080/1744666X.2021.1905525 http://scihub22266oqcxt.onion/10.1080/1744666X.2021.1905525 33745411!ä!33745411 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Expert+Rev+Clin+Immunol 2021 ; 17 (5): 421-430 Nephropedia Template TP {{tp|p=33745411|t=2021. Perspective: diagnostic laboratories should urgently develop T cell assays for SARS-CoV-2 infection |pdf=|usr=}}{{33745411}} gab.com Text Perspective: diagnostic laboratories should urgently develop T cell assays for SARS-CoV-2 infection JO: Expert Rev Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33745411 #FOAvip Introduction: Diagnostic tests play a critical role in the management of Sars-CoV-2, the virus responsible for COVID-19. There are two groups of tests, which are in widespread use to identify patients who have contracted the virus. The commonly used reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) test becomes negative once viral shedding ceases by approximately 2-3weeks. Antibody tests directed to viral antigens become positive after the second week of infection. IgG antibody responses to the virus are muted in children, pregnant females, and those with mild symptoms. IgA and IgM antibodies rapidly wane, although IgG antibodies directed to the receptor-binding domain (RBD) of the spike (S) glycoprotein are more durable. Current data show variability in the sensitivity of commercial and in-house antibody tests to SARS-CoV-2.Areas covered: The role of T cells in acute illness is uncertain, but long-term protection against the virus may rely on memory T cell responses. Measuring memory T cell responses is important for retrospective confirmation of cases, who may have been infected early in the pandemic before reliable RT-qPCR tests were available and whose SARS-CoV-2 antibodies may have become undetectable. Relevant peer-reviewed published references from PubMed are included up to 15 March 2021.Expert opinion: After surveying the literature, the authors present the case for urgent development of diagnostic T cell assays for SARS-CoV-2 by accredited laboratories. Twit Text FOAVip Perspective: diagnostic laboratories should urgently develop T cell assays for SARS-CoV-2 infection ????Expert Rev Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33745411 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33745411 #FOAvip English Wikipedia <ref>{{Cite pmid|33745411}}</ref> Perspective: diagnostic laboratories should urgently develop T cell assays for SARS-CoV-2 infection #MMPMID33745411 Ameratunga R; Woon ST; Jordan A; Longhurst H; Leung E; Steele R; Lehnert K; Snell R; Brooks AES Expert Rev Clin Immunol 2021[May]; 17 (5): 421-430 PMID33745411show ga Introduction: Diagnostic tests play a critical role in the management of Sars-CoV-2, the virus responsible for COVID-19. There are two groups of tests, which are in widespread use to identify patients who have contracted the virus. The commonly used reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) test becomes negative once viral shedding ceases by approximately 2-3weeks. Antibody tests directed to viral antigens become positive after the second week of infection. IgG antibody responses to the virus are muted in children, pregnant females, and those with mild symptoms. IgA and IgM antibodies rapidly wane, although IgG antibodies directed to the receptor-binding domain (RBD) of the spike (S) glycoprotein are more durable. Current data show variability in the sensitivity of commercial and in-house antibody tests to SARS-CoV-2.Areas covered: The role of T cells in acute illness is uncertain, but long-term protection against the virus may rely on memory T cell responses. Measuring memory T cell responses is important for retrospective confirmation of cases, who may have been infected early in the pandemic before reliable RT-qPCR tests were available and whose SARS-CoV-2 antibodies may have become undetectable. Relevant peer-reviewed published references from PubMed are included up to 15 March 2021.Expert opinion: After surveying the literature, the authors present the case for urgent development of diagnostic T cell assays for SARS-CoV-2 by accredited laboratories. |*Immunologic Memory[MESH] |COVID-19/*diagnosis/*immunology[MESH] |Humans[MESH] |Immunoassay[MESH] |SARS-CoV-2/*immunology[MESH]Perspective: diagnostic laboratories should urgently develop T cell as(epmc).pdf DeepDyve Pubget Overpricing