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10.1016/j.diagmicrobio.2021.115370

http://scihub22266oqcxt.onion/10.1016/j.diagmicrobio.2021.115370
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33744623!7954771!33744623
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suck abstract from ncbi


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pmid33744623      Diagn+Microbiol+Infect+Dis 2021 ; 100 (3): 115370
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  • Clinical evaluation of the antibody response in patients with COVID-19 using automated high-throughput immunoassays #MMPMID33744623
  • Kubota K; Kitagawa Y; Matsuoka M; Imai K; Orihara Y; Kawamura R; Sakai J; Ishibashi N; Tarumoto N; Takeuchi S; Maesaki S; Maeda T
  • Diagn Microbiol Infect Dis 2021[Jul]; 100 (3): 115370 PMID33744623show ga
  • Several automated high-throughput immunoassays for detecting anti-SARS-CoV-2 antibodies by a semi-quantitative approach have been commercialized. In this study, we describe the timeline of the antibody response in patients with RT-PCR-confirmed COVID-19. A total of 292 sequential serum samples from 33 Japanese patients were retrospectively analyzed using four test kits for SARS-CoV-2: the Abbott SARS-CoV-2 IgG assay (Abbott), Elecsys(R) Anti-SARS-CoV-2 assay (Roche Diagnostic), and VITROS(R) Anti-SARS-CoV-2 Total and IgG assays (Ortho Clinical Diagnostics). All automated immunoassays could equivalently identify positive sera collected within 2 weeks after symptom onset (99.3%-100%). In addition, the S protein-based automated immunoassay, the VITROS(R) Anti-SARS-CoV-2 Total assay, may play a complementary role in evaluating passive antibody therapies or vaccines against SARS-CoV-2, although further research is required.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |COVID-19 Serological Testing/*methods[MESH]
  • |COVID-19/*diagnosis/immunology[MESH]
  • |Female[MESH]
  • |High-Throughput Screening Assays[MESH]
  • |Humans[MESH]
  • |Immunoassay[MESH]
  • |Kinetics[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/*immunology/isolation & purification[MESH]


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