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10.1016/j.coviro.2021.02.006 http://scihub22266oqcxt.onion/10.1016/j.coviro.2021.02.006 33744490!7942143!33744490     free     free     free       Curr+Opin+Virol 2021 ; 47 (ä): 113-120 Nephropedia Template TP {{tp|p=33744490|t=2021. Coronavirus entry: how we arrived at SARS-CoV-2 |pdf=|usr=}}{{33744490}} gab.com Text Coronavirus entry: how we arrived at SARS-CoV-2 JO: Curr Opin Virol http://www.kidney.de/pget.php?&tw=1&pmid=33744490 #FOAvip Because of the COVID-19 pandemic, the novel coronavirus SARS-CoV-2 has risen to shape scientific research during 2020, with its spike (S) protein being a predominant focus. The S protein is likely the most complicated of all viral glycoproteins and is a key factor in immunological responses and virus pathogenesis. It is also the driving force dictating virus entry mechanisms, which are highly 'plastic' for coronaviruses, allowing a plethora of options for different virus variants and strains in different cell types. Here we review coronavirus entry as a foundation for current work on SARS-CoV-2. We focus on the post-receptor binding events and cellular pathways that direct the membrane fusion events necessary for genome delivery, including S proteolytic priming and activation. We also address aspects of the entry process important for virus evolution and therapeutic development. Twit Text FOAVip Coronavirus entry: how we arrived at SARS-CoV-2 ????Curr Opin Virol http://www.kidney.de/pget.php?&tw=1&pmid=33744490 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33744490 #FOAvip English Wikipedia <ref>{{Cite pmid|33744490}}</ref> Coronavirus entry: how we arrived at SARS-CoV-2 #MMPMID33744490 Whittaker GR; Daniel S; Millet JK Curr Opin Virol 2021[Apr]; 47 (ä): 113-120 PMID33744490show ga Because of the COVID-19 pandemic, the novel coronavirus SARS-CoV-2 has risen to shape scientific research during 2020, with its spike (S) protein being a predominant focus. The S protein is likely the most complicated of all viral glycoproteins and is a key factor in immunological responses and virus pathogenesis. It is also the driving force dictating virus entry mechanisms, which are highly 'plastic' for coronaviruses, allowing a plethora of options for different virus variants and strains in different cell types. Here we review coronavirus entry as a foundation for current work on SARS-CoV-2. We focus on the post-receptor binding events and cellular pathways that direct the membrane fusion events necessary for genome delivery, including S proteolytic priming and activation. We also address aspects of the entry process important for virus evolution and therapeutic development. |*Virus Internalization/drug effects[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*etiology/transmission[MESH] |Humans[MESH] |SARS-CoV-2/*physiology[MESH] |Signal Transduction/physiology[MESH]Coronavirus entry: how we arrived at SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing