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10.1016/j.eprac.2021.03.006

http://scihub22266oqcxt.onion/10.1016/j.eprac.2021.03.006
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33744444!7965847!33744444
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suck abstract from ncbi


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pmid33744444      Endocr+Pract 2021 ; 27 (5): 484-493
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  • Vitamin D and Its Potential Benefit for the COVID-19 Pandemic #MMPMID33744444
  • Charoenngam N; Shirvani A; Holick MF
  • Endocr Pract 2021[May]; 27 (5): 484-493 PMID33744444show ga
  • Vitamin D is known not only for its importance for bone health but also for its biologic activities on many other organ systems. This is due to the presence of the vitamin D receptor in various types of cells and tissues, including the skin, skeletal muscle, adipose tissue, endocrine pancreas, immune cells, and blood vessels. Experimental studies have shown that vitamin D exerts several actions that are thought to be protective against coronavirus disease (COVID-19) infectivity and severity. These include the immunomodulatory effects on the innate and adaptive immune systems, the regulatory effects on the renin-angiotensin-aldosterone-system in the kidneys and the lungs, and the protective effects against endothelial dysfunction and thrombosis. Prior to the COVID-19 pandemic, studies have shown that vitamin D supplementation is beneficial in protecting against risk of acquiring acute respiratory viral infection and may improve outcomes in sepsis and critically ill patients. There are a growing number of data connecting COVID-19 infectivity and severity with vitamin D status, suggesting a potential benefit of vitamin D supplementation for primary prevention or as an adjunctive treatment of COVID-19. Although the results from most ongoing randomized clinical trials aiming to prove the benefit of vitamin D supplementation for these purposes are still pending, there is no downside to increasing vitamin D intake and having sensible sunlight exposure to maintain serum 25-hydroxyvitamin D at a level of least 30 ng/mL (75 nmol/L) and preferably 40 to 60 ng/mL (100-150 nmol/L) to minimize the risk of COVID-19 infection and its severity.
  • |*COVID-19[MESH]
  • |*Pandemics/prevention & control[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2[MESH]
  • |Vitamin D[MESH]


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