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10.1016/j.cell.2021.02.033 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.02.033 33743891!7891044!33743891     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (8): 2201-2211.e7 Nephropedia Template TP {{tp|p=33743891|t=2021. Reduced neutralization of SARS-CoV-2 B 1 1 7 variant by convalescent and vaccine sera |pdf=|usr=}}{{33743891}} gab.com Text Reduced neutralization of SARS-CoV-2 B 1 1 7 variant by convalescent and vaccine sera JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33743891 #FOAvip SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the pandemic and error-prone virus replication is leading to the appearance of mutant viruses and potentially escape from antibody responses. Variant B.1.1.7, now dominant in the UK, with increased transmission, harbors 9 amino acid changes in the spike, including N501Y in the ACE2 interacting surface. We examine the ability of B.1.1.7 to evade antibody responses elicited by natural SARS-CoV-2 infection or vaccination. We map the impact of N501Y by structure/function analysis of a large panel of well-characterized monoclonal antibodies. B.1.1.7 is harder to neutralize than parental virus, compromising neutralization by some members of a major class of public antibodies through light-chain contacts with residue 501. However, widespread escape from monoclonal antibodies or antibody responses generated by natural infection or vaccination was not observed. Twit Text FOAVip Reduced neutralization of SARS-CoV-2 B 1 1 7 variant by convalescent and vaccine sera ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33743891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33743891 #FOAvip English Wikipedia <ref>{{Cite pmid|33743891}}</ref> Reduced neutralization of SARS-CoV-2 B 1 1 7 variant by convalescent and vaccine sera #MMPMID33743891 Supasa P; Zhou D; Dejnirattisai W; Liu C; Mentzer AJ; Ginn HM; Zhao Y; Duyvesteyn HME; Nutalai R; Tuekprakhon A; Wang B; Paesen GC; Slon-Campos J; Lopez-Camacho C; Hallis B; Coombes N; Bewley KR; Charlton S; Walter TS; Barnes E; Dunachie SJ; Skelly D; Lumley SF; Baker N; Shaik I; Humphries HE; Godwin K; Gent N; Sienkiewicz A; Dold C; Levin R; Dong T; Pollard AJ; Knight JC; Klenerman P; Crook D; Lambe T; Clutterbuck E; Bibi S; Flaxman A; Bittaye M; Belij-Rammerstorfer S; Gilbert S; Hall DR; Williams MA; Paterson NG; James W; Carroll MW; Fry EE; Mongkolsapaya J; Ren J; Stuart DI; Screaton GR Cell 2021[Apr]; 184 (8): 2201-2211.e7 PMID33743891show ga SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the pandemic and error-prone virus replication is leading to the appearance of mutant viruses and potentially escape from antibody responses. Variant B.1.1.7, now dominant in the UK, with increased transmission, harbors 9 amino acid changes in the spike, including N501Y in the ACE2 interacting surface. We examine the ability of B.1.1.7 to evade antibody responses elicited by natural SARS-CoV-2 infection or vaccination. We map the impact of N501Y by structure/function analysis of a large panel of well-characterized monoclonal antibodies. B.1.1.7 is harder to neutralize than parental virus, compromising neutralization by some members of a major class of public antibodies through light-chain contacts with residue 501. However, widespread escape from monoclonal antibodies or antibody responses generated by natural infection or vaccination was not observed. |Animals[MESH] |Antibodies, Monoclonal/*immunology[MESH] |Antibodies, Neutralizing/blood/*immunology[MESH] |Antibodies, Viral/blood/*immunology[MESH] |CHO Cells[MESH] |COVID-19/epidemiology/*immunology[MESH] |Chlorocebus aethiops[MESH] |Cricetulus[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Pandemics[MESH] |Protein Binding[MESH] |SARS-CoV-2/*immunology[MESH] |Spike Glycoprotein, Coronavirus/*immunology[MESH] |Structure-Activity Relationship[MESH]Reduced neutralization of SARS-CoV-2 B 1 1 7 variant by convalescent a(epmc).pdf DeepDyve Pubget Overpricing