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10.1016/j.cell.2021.03.013 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.03.013 33743213!7953441!33743213     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (9): 2372-2383.e9 Nephropedia Template TP {{tp|p=33743213|t=2021. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity |pdf=|usr=}}{{33743213}} gab.com Text Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33743213 #FOAvip Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of these variants, we evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2. Five of the 10 pseudoviruses, harboring receptor-binding domain mutations, including K417N/T, E484K, and N501Y, were highly resistant to neutralization. Cross-neutralization of B.1.351 variants was comparable to SARS-CoV and bat-derived WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape from vaccine responses. While the clinical impact of neutralization resistance remains uncertain, these results highlight the potential for variants to escape from neutralizing humoral immunity and emphasize the need to develop broadly protective interventions against the evolving pandemic. Twit Text FOAVip Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33743213 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33743213 #FOAvip English Wikipedia <ref>{{Cite pmid|33743213}}</ref> Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity #MMPMID33743213 Garcia-Beltran WF; Lam EC; St Denis K; Nitido AD; Garcia ZH; Hauser BM; Feldman J; Pavlovic MN; Gregory DJ; Poznansky MC; Sigal A; Schmidt AG; Iafrate AJ; Naranbhai V; Balazs AB Cell 2021[Apr]; 184 (9): 2372-2383.e9 PMID33743213show ga Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of these variants, we evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2. Five of the 10 pseudoviruses, harboring receptor-binding domain mutations, including K417N/T, E484K, and N501Y, were highly resistant to neutralization. Cross-neutralization of B.1.351 variants was comparable to SARS-CoV and bat-derived WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape from vaccine responses. While the clinical impact of neutralization resistance remains uncertain, these results highlight the potential for variants to escape from neutralizing humoral immunity and emphasize the need to develop broadly protective interventions against the evolving pandemic. |*Immunity, Humoral[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/*immunology[MESH] |BNT162 Vaccine[MESH] |COVID-19 Vaccines/*immunology[MESH] |COVID-19/blood/immunology/virology[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Mutation/genetics[MESH] |ROC Curve[MESH]Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced (epmc).pdf DeepDyve Pubget Overpricing