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10.1016/j.cell.2021.02.029 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.02.029 33743212!7885626!33743212     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33743212&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cell 2021 ; 184 (7): 1671-1692 Nephropedia Template TP {{tp|p=33743212|t=2021. COVID-19 and the human innate immune system |pdf=|usr=}}{{33743212}} gab.com Text COVID-19 and the human innate immune system JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33743212 #FOAvip The introduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the human population represents a tremendous medical and economic crisis. Innate immunity-as the first line of defense of our immune system-plays a central role in combating this novel virus. Here, we provide a conceptual framework for the interaction of the human innate immune system with SARS-CoV-2 to link the clinical observations with experimental findings that have been made during the first year of the pandemic. We review evidence that variability in innate immune system components among humans is a main contributor to the heterogeneous disease courses observed for coronavirus disease 2019 (COVID-19), the disease spectrum induced by SARS-CoV-2. A better understanding of the pathophysiological mechanisms observed for cells and soluble mediators involved in innate immunity is a prerequisite for the development of diagnostic markers and therapeutic strategies targeting COVID-19. However, this will also require additional studies addressing causality of events, which so far are lagging behind. Twit Text FOAVip COVID-19 and the human innate immune system ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33743212 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33743212 #FOAvip English Wikipedia <ref>{{Cite pmid|33743212}}</ref> COVID-19 and the human innate immune system #MMPMID33743212 Schultze JL; Aschenbrenner AC Cell 2021[Apr]; 184 (7): 1671-1692 PMID33743212show ga The introduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the human population represents a tremendous medical and economic crisis. Innate immunity-as the first line of defense of our immune system-plays a central role in combating this novel virus. Here, we provide a conceptual framework for the interaction of the human innate immune system with SARS-CoV-2 to link the clinical observations with experimental findings that have been made during the first year of the pandemic. We review evidence that variability in innate immune system components among humans is a main contributor to the heterogeneous disease courses observed for coronavirus disease 2019 (COVID-19), the disease spectrum induced by SARS-CoV-2. A better understanding of the pathophysiological mechanisms observed for cells and soluble mediators involved in innate immunity is a prerequisite for the development of diagnostic markers and therapeutic strategies targeting COVID-19. However, this will also require additional studies addressing causality of events, which so far are lagging behind. |*Host Microbial Interactions[MESH] |*Immunity, Innate[MESH] |COVID-19/*immunology[MESH] |Humans[MESH] |SARS-CoV-2/*physiology[MESH]COVID-19 and the human innate immune system (epmc).pdf DeepDyve Pubget Overpricing