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10.1016/j.cell.2021.03.012 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.03.012 33743211!7951565!33743211     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (9): 2394-2411.e16 Nephropedia Template TP {{tp|p=33743211|t=2021. Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions |pdf=|usr=}}{{33743211}} gab.com Text Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33743211 #FOAvip SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS), we identified 309 host proteins that bind the SARS-CoV-2 RNA during active infection. Integration of this data with ChIRP-MS data from three other RNA viruses defined viral specificity of RNA-host protein interactions. Targeted CRISPR screens revealed that the majority of functional RNA-binding proteins protect the host from virus-induced cell death, and comparative CRISPR screens across seven RNA viruses revealed shared and SARS-specific antiviral factors. Finally, by combining the RNA-centric approach and functional CRISPR screens, we demonstrated a physical and functional connection between SARS-CoV-2 and mitochondria, highlighting this organelle as a general platform for antiviral activity. Altogether, these data provide a comprehensive catalog of functional SARS-CoV-2 RNA-host protein interactions, which may inform studies to understand the host-virus interface and nominate host pathways that could be targeted for therapeutic benefit. Twit Text FOAVip Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33743211 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33743211 #FOAvip English Wikipedia <ref>{{Cite pmid|33743211}}</ref> Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions #MMPMID33743211 Flynn RA; Belk JA; Qi Y; Yasumoto Y; Wei J; Alfajaro MM; Shi Q; Mumbach MR; Limaye A; DeWeirdt PC; Schmitz CO; Parker KR; Woo E; Chang HY; Horvath TL; Carette JE; Bertozzi CR; Wilen CB; Satpathy AT Cell 2021[Apr]; 184 (9): 2394-2411.e16 PMID33743211show ga SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS), we identified 309 host proteins that bind the SARS-CoV-2 RNA during active infection. Integration of this data with ChIRP-MS data from three other RNA viruses defined viral specificity of RNA-host protein interactions. Targeted CRISPR screens revealed that the majority of functional RNA-binding proteins protect the host from virus-induced cell death, and comparative CRISPR screens across seven RNA viruses revealed shared and SARS-specific antiviral factors. Finally, by combining the RNA-centric approach and functional CRISPR screens, we demonstrated a physical and functional connection between SARS-CoV-2 and mitochondria, highlighting this organelle as a general platform for antiviral activity. Altogether, these data provide a comprehensive catalog of functional SARS-CoV-2 RNA-host protein interactions, which may inform studies to understand the host-virus interface and nominate host pathways that could be targeted for therapeutic benefit. |*Host-Pathogen Interactions[MESH] |Animals[MESH] |COVID-19/virology[MESH] |CRISPR-Cas Systems/genetics[MESH] |Cell Line, Tumor[MESH] |Chlorocebus aethiops[MESH] |Female[MESH] |Genome, Viral[MESH] |Humans[MESH] |Lung/virology[MESH] |Male[MESH] |Mass Spectrometry[MESH] |Mitochondria/metabolism/ultrastructure[MESH] |Proteome/metabolism[MESH] |RNA, Viral/*genetics[MESH] |RNA-Binding Proteins/metabolism[MESH] |SARS-CoV-2/*genetics/ultrastructure[MESH]Discovery and functional interrogation of SARS-CoV-2 RNA-host protein (epmc).pdf DeepDyve Pubget Overpricing