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10.1002/mrc.5154

http://scihub22266oqcxt.onion/10.1002/mrc.5154
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33742475!ä!33742475

suck abstract from ncbi


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pmid33742475      Magn+Reson+Chem 2021 ; 59 (7): 746-751
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  • Plain (1) H nuclear magnetic resonance analysis streamlines the quality control of antiviral favipiravir and congeneric World Health Organization essential medicines #MMPMID33742475
  • Achanta PS; Chen SN; Pauli GF
  • Magn Reson Chem 2021[Jul]; 59 (7): 746-751 PMID33742475show ga
  • Favipiravir is an established antiviral that is currently being assessed as an investigational drug for the treatment of COVID-19. Favipiravir is strikingly similar to two molecules that the World Health Organization (WHO) lists as essential medicines, which also consist of a six-membered aromatic N-heterocycle bearing a carboxamide function: the anti-tuberculosis agent, pyrazinamide, and nicotinamide, also known as vitamin B(3) . We demonstrate the utility of (1) H nuclear magnetic resonance (NMR) profiling, an emerging pharmacopoeial tool, for the highly specific identification, selective differentiation of congeners, and subsequent detection of drug falsification or adulteration of these medicines. The straightforward comparison of basic 1-D (1) H NMR spectra, obtained with benchtop or advanced NMR instruments alike, offers a rapid identity assay and works independently of physical reference materials. This approach accelerates and advances pharmaceutical quality control measures under situations of increased drug demand and altered economy, such as during a pandemic.
  • |*Quality Control[MESH]
  • |Amides/*analysis/chemistry[MESH]
  • |Antiviral Agents/*analysis/chemistry[MESH]
  • |Drug Contamination/*prevention & control[MESH]
  • |Niacinamide/*analysis/chemistry[MESH]
  • |Proton Magnetic Resonance Spectroscopy[MESH]
  • |Pyrazinamide/*analysis/chemistry[MESH]
  • |Pyrazines/*analysis/chemistry[MESH]


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