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10.1111/bcp.14826 http://scihub22266oqcxt.onion/10.1111/bcp.14826 33742473!8250380!33742473     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Clin+Pharmacol 2021 ; 87 (10): 3737-3746 Nephropedia Template TP {{tp|p=33742473|t=2021. Zinc supplementation as an adjunct therapy for COVID-19: Challenges and opportunities |pdf=|usr=}}{{33742473}} gab.com Text Zinc supplementation as an adjunct therapy for COVID-19: Challenges and opportunities JO: Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33742473 #FOAvip An outbreak of a novel coronavirus (COVID-19 or 2019-CoV) infection has posed significant threats to international health and the economy. Patients with COVID-19 are at risk of cytokine storm, acute respiratory distress syndrome (ARDS), reduced blood oxygenation, mechanical ventilation, and a high death rate. Although recent studies have shown remdesivir and dexamethasone as treatment options, there is an urgent need to find a treatment to inhibit virus replication and to control the progression of the disease. Essential biometal zinc has generated a lot of excitement as one of the promising candidates to reduce the severity of COVID-19 infection. Several published observations outlined in the review are the reasons why there is a global enthusiasm that zinc therapy could be a possible therapeutic option. However, the biggest challenge in realising the therapeutic value of zinc is lack of optimal treatment modalities such as dose, duration of zinc supplementation and the mode of delivery. In this review, we discuss the regulatory mechanism that hinges upon the bioavailability of zinc. Finally, we propose that intravenous zinc could circumvent the confounding factors affecting the bioavailability of zinc and allow zinc to achieve its therapeutic potential. If successful, due to advantages such as lack of toxicity, low cost and ease of availability, intravenous zinc could be rapidly implemented clinically. Twit Text FOAVip Zinc supplementation as an adjunct therapy for COVID-19: Challenges and opportunities ????Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33742473 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33742473 #FOAvip English Wikipedia <ref>{{Cite pmid|33742473}}</ref> Zinc supplementation as an adjunct therapy for COVID-19: Challenges and opportunities #MMPMID33742473 Chinni V; El-Khoury J; Perera M; Bellomo R; Jones D; Bolton D; Ischia J; Patel O Br J Clin Pharmacol 2021[Oct]; 87 (10): 3737-3746 PMID33742473show ga An outbreak of a novel coronavirus (COVID-19 or 2019-CoV) infection has posed significant threats to international health and the economy. Patients with COVID-19 are at risk of cytokine storm, acute respiratory distress syndrome (ARDS), reduced blood oxygenation, mechanical ventilation, and a high death rate. Although recent studies have shown remdesivir and dexamethasone as treatment options, there is an urgent need to find a treatment to inhibit virus replication and to control the progression of the disease. Essential biometal zinc has generated a lot of excitement as one of the promising candidates to reduce the severity of COVID-19 infection. Several published observations outlined in the review are the reasons why there is a global enthusiasm that zinc therapy could be a possible therapeutic option. However, the biggest challenge in realising the therapeutic value of zinc is lack of optimal treatment modalities such as dose, duration of zinc supplementation and the mode of delivery. In this review, we discuss the regulatory mechanism that hinges upon the bioavailability of zinc. Finally, we propose that intravenous zinc could circumvent the confounding factors affecting the bioavailability of zinc and allow zinc to achieve its therapeutic potential. If successful, due to advantages such as lack of toxicity, low cost and ease of availability, intravenous zinc could be rapidly implemented clinically. |*COVID-19[MESH] |Cytokine Release Syndrome[MESH] |Dietary Supplements[MESH] |Humans[MESH] |SARS-CoV-2[MESH]Zinc supplementation as an adjunct therapy for COVID-19: Challenges an(epmc).pdf DeepDyve Pubget Overpricing