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10.1038/s41541-021-00301-y http://scihub22266oqcxt.onion/10.1038/s41541-021-00301-y 33741993!7979827!33741993     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33741993&cmd=llinks): Failed to open stream: HTTP request failed! 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Ad26 COV2 S protects Syrian hamsters against G614 spike variant SARS-CoV-2 and does not enhance respiratory disease |pdf=|usr=}}{{33741993}} gab.com Text Ad26 COV2 S protects Syrian hamsters against G614 spike variant SARS-CoV-2 and does not enhance respiratory disease JO: NPJ Vaccines http://www.kidney.de/pget.php?&tw=1&pmid=33741993 #FOAvip Previously we have shown that a single dose of recombinant adenovirus serotype 26 (Ad26) vaccine expressing a prefusion stabilized SARS-CoV-2 spike antigen (Ad26.COV2.S) is immunogenic and provides protection in Syrian hamster and non-human primate SARS-CoV-2 infection models. Here, we investigated the immunogenicity, protective efficacy, and potential for vaccine-associated enhanced respiratory disease (VAERD) mediated by Ad26.COV2.S in a moderate disease Syrian hamster challenge model, using the currently most prevalent G614 spike SARS-CoV-2 variant. Vaccine doses of 1 x 10(9) and 1 x 10(10) VP elicited substantial neutralizing antibodies titers and completely protected over 80% of SARS-CoV-2 inoculated Syrian hamsters from lung infection and pneumonia but not upper respiratory tract infection. A second vaccine dose further increased neutralizing antibody titers that was associated with decreased infectious viral load in the upper respiratory tract after SARS-CoV-2 challenge. Suboptimal non-protective immune responses elicited by low-dose A26.COV2.S vaccination did not exacerbate respiratory disease in SARS-CoV-2-inoculated Syrian hamsters with breakthrough infection. In addition, dosing down the vaccine allowed to establish that binding and neutralizing antibody titers correlate with lower respiratory tract protection probability. Overall, these preclinical data confirm efficacy of a one-dose vaccine regimen with Ad26.COV2.S in this G614 spike SARS-CoV-2 virus variant Syrian hamster model, show the added benefit of a second vaccine dose, and demonstrate that there are no signs of VAERD under conditions of suboptimal immunity. Twit Text FOAVip Ad26 COV2 S protects Syrian hamsters against G614 spike variant SARS-CoV-2 and does not enhance respiratory disease ????NPJ Vaccines http://www.kidney.de/pget.php?&tw=1&pmid=33741993 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33741993 #FOAvip English Wikipedia <ref>{{Cite pmid|33741993}}</ref> Ad26 COV2 S protects Syrian hamsters against G614 spike variant SARS-CoV-2 and does not enhance respiratory disease #MMPMID33741993 van der Lubbe JEM; Rosendahl Huber SK; Vijayan A; Dekking L; van Huizen E; Vreugdenhil J; Choi Y; Baert MRM; Feddes-de Boer K; Izquierdo Gil A; van Heerden M; Dalebout TJ; Myeni SK; Kikkert M; Snijder EJ; de Waal L; Stittelaar KJ; Tolboom JTBM; Serroyen J; Muchene L; van der Fits L; Rutten L; Langedijk JPM; Barouch DH; Schuitemaker H; Zahn RC; Wegmann F NPJ Vaccines 2021[Mar]; 6 (1): 39 PMID33741993show ga Previously we have shown that a single dose of recombinant adenovirus serotype 26 (Ad26) vaccine expressing a prefusion stabilized SARS-CoV-2 spike antigen (Ad26.COV2.S) is immunogenic and provides protection in Syrian hamster and non-human primate SARS-CoV-2 infection models. Here, we investigated the immunogenicity, protective efficacy, and potential for vaccine-associated enhanced respiratory disease (VAERD) mediated by Ad26.COV2.S in a moderate disease Syrian hamster challenge model, using the currently most prevalent G614 spike SARS-CoV-2 variant. Vaccine doses of 1 x 10(9) and 1 x 10(10) VP elicited substantial neutralizing antibodies titers and completely protected over 80% of SARS-CoV-2 inoculated Syrian hamsters from lung infection and pneumonia but not upper respiratory tract infection. A second vaccine dose further increased neutralizing antibody titers that was associated with decreased infectious viral load in the upper respiratory tract after SARS-CoV-2 challenge. Suboptimal non-protective immune responses elicited by low-dose A26.COV2.S vaccination did not exacerbate respiratory disease in SARS-CoV-2-inoculated Syrian hamsters with breakthrough infection. In addition, dosing down the vaccine allowed to establish that binding and neutralizing antibody titers correlate with lower respiratory tract protection probability. Overall, these preclinical data confirm efficacy of a one-dose vaccine regimen with Ad26.COV2.S in this G614 spike SARS-CoV-2 virus variant Syrian hamster model, show the added benefit of a second vaccine dose, and demonstrate that there are no signs of VAERD under conditions of suboptimal immunity. äAd26 COV2 S protects Syrian hamsters against G614 spike variant SARS-C(epmc).pdf DeepDyve Pubget Overpricing