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10.1016/j.cell.2021.02.013

http://scihub22266oqcxt.onion/10.1016/j.cell.2021.02.013
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33740455!ä!33740455

suck abstract from ncbi


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pmid33740455      Cell 2021 ; 184 (6): 1604-1620
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  • Antivirals with common targets against highly pathogenic viruses #MMPMID33740455
  • Lu L; Su S; Yang H; Jiang S
  • Cell 2021[Mar]; 184 (6): 1604-1620 PMID33740455show ga
  • Historically, emerging viruses appear constantly and have cost millions of human lives. Currently, climate change and intense globalization have created favorable conditions for viral transmission. Therefore, effective antivirals, especially those targeting the conserved protein in multiple unrelated viruses, such as the compounds targeting RNA-dependent RNA polymerase, are urgently needed to combat more emerging and re-emerging viruses in the future. Here we reviewed the development of antivirals with common targets, including those against the same protein across viruses, or the same viral function, to provide clues for development of antivirals for future epidemics.
  • |*Pandemics[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/pharmacology/*therapeutic use[MESH]
  • |Communicable Diseases, Emerging/*drug therapy/*epidemiology/virology[MESH]
  • |Humans[MESH]
  • |Molecular Targeted Therapy/*methods[MESH]
  • |RNA-Dependent RNA Polymerase/antagonists & inhibitors[MESH]
  • |Viral Envelope Proteins/antagonists & inhibitors[MESH]
  • |Virus Diseases/*drug therapy/*epidemiology/virology[MESH]
  • |Virus Internalization/drug effects[MESH]


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