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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Inflamm+Res 2021 ; 70 (4): 375-377 Nephropedia Template TP
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Association of alpha-1-antitrypsin deficiency with vitamin D status: who is most at risk of getting severe COVID-19? #MMPMID33740066
Shimi G; Zand H
Inflamm Res 2021[Apr]; 70 (4): 375-377 PMID33740066show ga
INTRODUCTION: Coronavirus disease 2019 (COVID-19), a new disease that we do not know yet how to treat, is rapidly evolving and has forced us to stay indoors. Surprisingly, a broad range of symptoms has been reported since COVID-19 emergence. Individual variations in susceptibility to SARS-CoV-2 can be due to non-genetic and genetic factors. Alpha-1-antitrypsin deficiency (AATD) is an inherited condition that is associated with an increased risk of liver and lung diseases which may increase susceptibility to COVID-19 infection. At the same time, there could be a possibility of developing non-hereditary AATD. DISCUSSION: In addition to some evidence showing the role of vitamin D deficiency in COVID-19 pathology, it has been recognized that there is a biological link between AAT and vitamin D. Therefore, here we offer a new perspective that lower vitamin D levels in COVID-19 patients can cause acquired AATD that provide a condition with more disease severity and a higher risk of death. As a consequence, COVID-19 individuals with vitamin D deficiency may have a higher risk of morbidity and mortality. CONCLUSION: Therefore, early vitamin D and AAT assessments and optimal interventions could be helpful to prevent severe COVID-19 outcomes.
|COVID-19/*blood/*complications[MESH]
|Disease Susceptibility[MESH]
|Humans[MESH]
|Liver Diseases/complications[MESH]
|Lung Diseases/complications[MESH]
|Risk Factors[MESH]
|Severity of Illness Index[MESH]
|Treatment Outcome[MESH]
|Vitamin D Deficiency/*complications/mortality[MESH]