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10.1002/cbin.11593 http://scihub22266oqcxt.onion/10.1002/cbin.11593 33739565!ä!33739565 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Biol+Int 2021 ; 45 (7): 1533-1545 Nephropedia Template TP {{tp|p=33739565|t=2021. Calcium activity in response to nAChR ligands in murine bone marrow granulocytes with different Gr-1 expression |pdf=|usr=}}{{33739565}} gab.com Text Calcium activity in response to nAChR ligands in murine bone marrow granulocytes with different Gr-1 expression JO: Cell Biol Int http://www.kidney.de/pget.php?&tw=1&pmid=33739565 #FOAvip Polymorphonuclear neutrophilic granulocytes (PMNs) are the largest proportion of leukocytes in adult human blood that perform numerous functions, including phagocytosis, degranulation, generation of reactive oxygen species, and NETosis. Excessive neutrophil activity associates with hyperinflammation and tissue damage during pathologies such as inflammatory bowel disease, diabetes mellitus, tuberculosis, and coronavirus disease 2019. Nicotinic acetylcholine receptors (nAChRs) can modulate immune cells, including neutrophils, functions, therefore, nAChR ligands are considered as the potent agents for therapy of inflammation. Earlier it was shown, that about 30% of PMNs from the acute inflammatory site responded to nicotine by calcium spikes. In this study, we studied the generation of calcium spikes in murine granulocytes with different maturity level (evaluated by Gr-1 expression) isolated from bone marrow in response to ligands of nAChRs in control and under chronic nicotine consumption. It was found that nearly 20%-25% cells in the granulocyte population responded to nicotine or selective antagonists of different type of nAChRs (alpha-cobratoxin, GIC, and Vc1.1). We demonstrated that in the control group Ca(2+) -mobilizing activity was regulated through alpha7 and alpha9alpha10 nAChRs in immature granulocytes (Gr-1(int) ), whereas in mature granulocytes (Gr-1(hi) ) it was regulated through alpha7, alpha3beta2, and alpha9-contained nAChRs. Sensitivity of PMNs to nicotine depended on their maturity level after chronic nicotine consumption. Gr-1(int) cells responded to nicotine through alpha7 and alpha9-contained nAChRs, while Gr-1(hi) did not respond to nicotine. Thus, calcium response to nAChR ligands in bone marrow PMNs depends on their maturity level. Twit Text FOAVip Calcium activity in response to nAChR ligands in murine bone marrow granulocytes with different Gr-1 expression ????Cell Biol Int http://www.kidney.de/pget.php?&tw=1&pmid=33739565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33739565 #FOAvip English Wikipedia <ref>{{Cite pmid|33739565}}</ref> Calcium activity in response to nAChR ligands in murine bone marrow granulocytes with different Gr-1 expression #MMPMID33739565 Serov D; Tikhonova I; Safronova V; Astashev M Cell Biol Int 2021[Jul]; 45 (7): 1533-1545 PMID33739565show ga Polymorphonuclear neutrophilic granulocytes (PMNs) are the largest proportion of leukocytes in adult human blood that perform numerous functions, including phagocytosis, degranulation, generation of reactive oxygen species, and NETosis. Excessive neutrophil activity associates with hyperinflammation and tissue damage during pathologies such as inflammatory bowel disease, diabetes mellitus, tuberculosis, and coronavirus disease 2019. Nicotinic acetylcholine receptors (nAChRs) can modulate immune cells, including neutrophils, functions, therefore, nAChR ligands are considered as the potent agents for therapy of inflammation. Earlier it was shown, that about 30% of PMNs from the acute inflammatory site responded to nicotine by calcium spikes. In this study, we studied the generation of calcium spikes in murine granulocytes with different maturity level (evaluated by Gr-1 expression) isolated from bone marrow in response to ligands of nAChRs in control and under chronic nicotine consumption. It was found that nearly 20%-25% cells in the granulocyte population responded to nicotine or selective antagonists of different type of nAChRs (alpha-cobratoxin, GIC, and Vc1.1). We demonstrated that in the control group Ca(2+) -mobilizing activity was regulated through alpha7 and alpha9alpha10 nAChRs in immature granulocytes (Gr-1(int) ), whereas in mature granulocytes (Gr-1(hi) ) it was regulated through alpha7, alpha3beta2, and alpha9-contained nAChRs. Sensitivity of PMNs to nicotine depended on their maturity level after chronic nicotine consumption. Gr-1(int) cells responded to nicotine through alpha7 and alpha9-contained nAChRs, while Gr-1(hi) did not respond to nicotine. Thus, calcium response to nAChR ligands in bone marrow PMNs depends on their maturity level. |Animals[MESH] |Antigens, Ly/*metabolism[MESH] |Bone Marrow Cells/*drug effects/metabolism[MESH] |Calcium Signaling/*drug effects[MESH] |Calcium/*metabolism[MESH] |Cells, Cultured[MESH] |Cholinergic Agents/*pharmacology[MESH] |Granulocytes/*drug effects/metabolism[MESH] |Ligands[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Nicotine/pharmacology[MESH] |Nicotinic Agonists/pharmacology[MESH] |Nicotinic Antagonists/pharmacology[MESH]Calcium activity in response to nAChR ligands in murine bone marrow gr(epmc).pdf DeepDyve Pubget Overpricing