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10.1002/jmv.26951

http://scihub22266oqcxt.onion/10.1002/jmv.26951
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33739452!8250955!33739452
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suck abstract from ncbi


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pmid33739452      J+Med+Virol 2021 ; 93 (7): 4358-4369
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  • The inflammatory markers of multisystem inflammatory syndrome in children (MIS-C) and adolescents associated with COVID-19: A meta-analysis #MMPMID33739452
  • Zhao Y; Yin L; Patel J; Tang L; Huang Y
  • J Med Virol 2021[Jul]; 93 (7): 4358-4369 PMID33739452show ga
  • To conduct a systematic review and meta-analysis to characterize inflammatory markers in comparisons of multisystem inflammatory syndrome in children (MIS-C) versus severe/non-severe COVID-19, severe MIS-C versus non-severe MIS-C, and among age groups of MIS-C. Nine databases were searched for studies on inflammatory markers of MIS-C. After quality checks, data were pooled using a fixed or random effects model. Inflammatory markers included white blood cell count (WBC) or leukocytes, absolute lymphocyte count (ALC), absolute neutrophil count (ANC), platelet count (PLT), C-reactive protein (CRP), procalcitonin (PCT), ferritin, D-dimer, lactate dehydrogenase (LDH), fibrinogen, and erythrocyte sedimentation rate (ESR) for comparisons by severity and age. Twenty-one studies with 1735 participants yielded 787 MIS-C patients. Compared to non-severe COVID-19 patients, MIS-C patients had lower ALC and higher ANC, CRP, and D-dimer levels. Compared to severe COVID-19 patients, MIS-C patients had lower LDH and PLT counts and higher ESR levels. Severe MIS-C patients had higher levels of WBC, ANC, CRP, D-dimer, and ferritin than non-severe MIS-C patients. For MIS-C, younger children (0-5 years) had lower CRP and ferritin levels than middle-aged/older children/adolescents. Measurement of inflammatory markers might assist clinicians in accurate evaluation and diagnosis of MIS-C and the associated disorders.
  • |Adolescent[MESH]
  • |Biomarkers/analysis/blood[MESH]
  • |Blood Sedimentation[MESH]
  • |C-Reactive Protein/analysis[MESH]
  • |COVID-19/*blood/*diagnosis/pathology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Ferritins/blood[MESH]
  • |Fibrin Fibrinogen Degradation Products/analysis[MESH]
  • |Fibrinogen/analysis[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |L-Lactate Dehydrogenase/blood[MESH]
  • |Leukocyte Count[MESH]
  • |Lymphocyte Count[MESH]
  • |Lymphocytes/cytology[MESH]
  • |Neutrophils/cytology[MESH]
  • |Platelet Count[MESH]
  • |Procalcitonin/blood[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Systemic Inflammatory Response Syndrome/*blood/*diagnosis/pathology[MESH]


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