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10.1080/14787210.2021.1905519

http://scihub22266oqcxt.onion/10.1080/14787210.2021.1905519
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33739215!8022339!33739215
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suck abstract from ncbi


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pmid33739215      Expert+Rev+Anti+Infect+Ther 2021 ; 19 (10): 1245-1258
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  • Vitamin D and immuno-pathology of COVID-19: many interactions but uncertain therapeutic benefits #MMPMID33739215
  • Banerjee A; Ganguly U; Saha S; Chakrabarti S; Saini RV; Rawal RK; Saso L; Chakrabarti S
  • Expert Rev Anti Infect Ther 2021[Oct]; 19 (10): 1245-1258 PMID33739215show ga
  • Introduction: COVID-19 pandemic has caused huge loss of human lives and extensive socio-economic damages. The immuno-pathology of this disease is neither clearly understood nor there are effective drugs for severe cases of COVID-19. Repurposing of available drugs for the treatment of COVID-19 is imperative.Areas Covered: This review has gathered the evidence from PubMed, Google Scholar, WHO, and other reliable websites on COVID-19 and summarized the existing knowledge of the immuno-pathology of COVID-19. We elucidated how vitamin D through its diverse actions on immune effector cells, epithelial cells, or renin-angiotensin-aldosterone system could have a modulatory role on the pathogenic mechanisms of COVID-19. The epidemiological evidence associating vitamin D deficiency with the severity and incidence of COVID-19 is also presented. However, the evidence of clinical benefit to patients of COVID-19 from randomized controlled trials with vitamin D has not come as yet.Expert opinion: It is now established that fatality of COVID-19 is primarily determined by hyperactivation of the host's innate immune system in response to SARS-CoV-2 invasion, and thus the research on the immuno-modulatory and other roles of vitamin D against viral infections should be pursued vigorously. This would be also useful for future pandemics caused by other novel viruses.
  • |Angiotensin-Converting Enzyme 2/metabolism[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/epidemiology/*immunology/*pathology[MESH]
  • |Comorbidity[MESH]
  • |Humans[MESH]
  • |Immunity, Innate[MESH]
  • |Immunomodulation/drug effects[MESH]
  • |Renin-Angiotensin System/drug effects[MESH]
  • |SARS-CoV-2/*immunology/physiology[MESH]
  • |Severity of Illness Index[MESH]
  • |Virus Replication[MESH]
  • |Vitamin D Deficiency/epidemiology[MESH]


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