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10.1002/ame2.12155 http://scihub22266oqcxt.onion/10.1002/ame2.12155 33738432!7954823!33738432     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33738432&cmd=llinks): Failed to open stream: HTTP request failed! 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SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice |pdf=|usr=}}{{33738432}} gab.com Text SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice JO: Animal Model Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=33738432 #FOAvip BACKGROUND: Cardiovascular diseases (CVDs) and diabetes mellitus (DM) are top two chronic comorbidities that increase the severity and mortality of COVID-19. However, how SARS-CoV-2 alters the progression of chronic diseases remain unclear. METHODS: We used adenovirus to deliver h-ACE2 to lung to enable SARS-CoV-2 infection in mice. SARS-CoV-2's impacts on pathogenesis of chronic diseases were studied through histopathological, virologic and molecular biology analysis. RESULTS: Pre-existing CVDs resulted in viral invasion, ROS elevation and activation of apoptosis pathways contribute myocardial injury during SARS-CoV-2 infection. Viral infection increased fasting blood glucose and reduced insulin response in DM model. Bone mineral density decreased shortly after infection, which associated with impaired PI3K/AKT/mTOR signaling. CONCLUSION: We established mouse models mimicked the complex pathological symptoms of COVID-19 patients with chronic diseases. Pre-existing diseases could impair the inflammatory responses to SARS-CoV-2 infection, which further aggravated the pre-existing diseases. This work provided valuable information to better understand the interplay between the primary diseases and SARS-CoV-2 infection. Twit Text FOAVip SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice ????Animal Model Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=33738432 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33738432 #FOAvip English Wikipedia <ref>{{Cite pmid|33738432}}</ref> SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice #MMPMID33738432 Ma Y; Lu D; Bao L; Qu Y; Liu J; Qi X; Yu L; Zhang X; Qi F; Lv Q; Liu Y; Shi X; Sun C; Li J; Wang J; Han Y; Gao K; Dong W; Liu N; Gao S; Xue J; Wei Q; Pan S; Gao H; Zhang L; Qin C Animal Model Exp Med 2021[Mar]; 4 (1): 2-15 PMID33738432show ga BACKGROUND: Cardiovascular diseases (CVDs) and diabetes mellitus (DM) are top two chronic comorbidities that increase the severity and mortality of COVID-19. However, how SARS-CoV-2 alters the progression of chronic diseases remain unclear. METHODS: We used adenovirus to deliver h-ACE2 to lung to enable SARS-CoV-2 infection in mice. SARS-CoV-2's impacts on pathogenesis of chronic diseases were studied through histopathological, virologic and molecular biology analysis. RESULTS: Pre-existing CVDs resulted in viral invasion, ROS elevation and activation of apoptosis pathways contribute myocardial injury during SARS-CoV-2 infection. Viral infection increased fasting blood glucose and reduced insulin response in DM model. Bone mineral density decreased shortly after infection, which associated with impaired PI3K/AKT/mTOR signaling. CONCLUSION: We established mouse models mimicked the complex pathological symptoms of COVID-19 patients with chronic diseases. Pre-existing diseases could impair the inflammatory responses to SARS-CoV-2 infection, which further aggravated the pre-existing diseases. This work provided valuable information to better understand the interplay between the primary diseases and SARS-CoV-2 infection. |Animals[MESH] |COVID-19/*complications/*physiopathology[MESH] |Cardiovascular Diseases/*complications/*physiopathology[MESH] |Comorbidity[MESH] |Diabetes Complications/*physiopathology[MESH] |Diabetes Mellitus[MESH] |Disease Models, Animal[MESH] |Male[MESH] |Mice[MESH]SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascula(epmc).pdf DeepDyve Pubget Overpricing