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10.1038/s41598-021-85788-0

http://scihub22266oqcxt.onion/10.1038/s41598-021-85788-0
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suck abstract from ncbi


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pmid33737694      Sci+Rep 2021 ; 11 (1): 6350
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  • Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients #MMPMID33737694
  • Paez-Franco JC; Torres-Ruiz J; Sosa-Hernandez VA; Cervantes-Diaz R; Romero-Ramirez S; Perez-Fragoso A; Meza-Sanchez DE; German-Acacio JM; Maravillas-Montero JL; Mejia-Dominguez NR; Ponce-de-Leon A; Ulloa-Aguirre A; Gomez-Martin D; Llorente L
  • Sci Rep 2021[Mar]; 11 (1): 6350 PMID33737694show ga
  • We identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three alpha-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversion of alpha-keto-acids to alpha- hydroxyl-acids helps to maintain NAD recycling in patients with altered oxygen levels, highlighting the potential relevance of amino acid supplementation during SARS-CoV-2 infection.
  • |Adult[MESH]
  • |Amino Acids/*metabolism[MESH]
  • |COVID-19/*metabolism[MESH]
  • |Case-Control Studies[MESH]
  • |Female[MESH]
  • |Homeostasis[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Metabolomics[MESH]
  • |Middle Aged[MESH]
  • |Mitochondria/metabolism[MESH]


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