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10.1016/j.bjid.2021.101569

http://scihub22266oqcxt.onion/10.1016/j.bjid.2021.101569
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33736948!7959266!33736948
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suck abstract from ncbi


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pmid33736948      Braz+J+Infect+Dis 2021 ; 25 (2): 101569
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  • Serum ferritin at admission in hospitalized COVID-19 patients as a predictor of mortality #MMPMID33736948
  • Lino K; Guimaraes GMC; Alves LS; Oliveira AC; Faustino R; Fernandes CS; Tupinamba G; Medeiros T; Silva AAD; Almeida JR
  • Braz J Infect Dis 2021[Mar]; 25 (2): 101569 PMID33736948show ga
  • INTRODUCTION: Some COVID-19 patients have higher mortality and the responsible factors for this unfavorable outcome is still not well understood. OBJECTIVE: To study the association between ferritin levels at admission, representing an inflammatory state, and hospital mortality in COVID-19 patients. METHODS: From May through July 2020, SARS-CoV-2 positive patients with moderate to severe clinical symptoms were evaluated at admission, regarding clinical and laboratory data on renal and hepatic function, hematologic parameters, cytomegalovirus co-infection, and acute phase proteins. RESULTS: A total of 97 patients were included; mean age=59.9+/-16.3 years, 58.8% male, 57.7% non-white, in-hospital mortality=45.4%. Age, ferritin, C-reactive protein, serum albumin and creatinine were significantly associated with mortality. Ferritin showed area under the curve (AUC) of 0.79 (p<0.001) for the cut-off of 1873.0ng/mL, sensitivity of 68.4% and specificity of 79.3% in predicting in-hospital mortality. Age >/=60 years had an odds ratio (OR) of 10.5 (95% CI=1.8-59.5; p=0.008) and ferritin >/=1873.0ng/mL had an OR of 6.0 (95% CI=1.4-26.2; p=0.016), both independently associated with mortality based on logistic regression analysis. CONCLUSION: The magnitude of inflammation present at admission of COVID-19 patients, represented by high ferritin levels, is independently predictive of in-hospital mortality.
  • |*COVID-19[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Female[MESH]
  • |Ferritins[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]


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