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10.1016/j.cell.2021.02.015 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.02.015 33735607!9196326!33735607     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (7): 1790-1803.e17 Nephropedia Template TP {{tp|p=33735607|t=2021. B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells |pdf=|usr=}}{{33735607}} gab.com Text B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33735607 #FOAvip The long non-coding RNA (lncRNA) XIST establishes X chromosome inactivation (XCI) in female cells in early development and thereafter is thought to be largely dispensable. Here, we show XIST is continually required in adult human B cells to silence a subset of X-linked immune genes such as TLR7. XIST-dependent genes lack promoter DNA methylation and require continual XIST-dependent histone deacetylation. XIST RNA-directed proteomics and CRISPRi screen reveal distinctive somatic cell-type-specific XIST complexes and identify TRIM28 that mediates Pol II pausing at promoters of X-linked genes in B cells. Single-cell transcriptome data of female patients with either systemic lupus erythematosus or COVID-19 infection revealed XIST dysregulation, reflected by escape of XIST-dependent genes, in CD11c(+) atypical memory B cells (ABCs). XIST inactivation with TLR7 agonism suffices to promote isotype-switched ABCs. These results indicate cell-type-specific diversification and function for lncRNA-protein complexes and suggest expanded roles for XIST in sex-differences in biology and medicine. Twit Text FOAVip B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33735607 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33735607 #FOAvip English Wikipedia <ref>{{Cite pmid|33735607}}</ref> B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells #MMPMID33735607 Yu B; Qi Y; Li R; Shi Q; Satpathy AT; Chang HY Cell 2021[Apr]; 184 (7): 1790-1803.e17 PMID33735607show ga The long non-coding RNA (lncRNA) XIST establishes X chromosome inactivation (XCI) in female cells in early development and thereafter is thought to be largely dispensable. Here, we show XIST is continually required in adult human B cells to silence a subset of X-linked immune genes such as TLR7. XIST-dependent genes lack promoter DNA methylation and require continual XIST-dependent histone deacetylation. XIST RNA-directed proteomics and CRISPRi screen reveal distinctive somatic cell-type-specific XIST complexes and identify TRIM28 that mediates Pol II pausing at promoters of X-linked genes in B cells. Single-cell transcriptome data of female patients with either systemic lupus erythematosus or COVID-19 infection revealed XIST dysregulation, reflected by escape of XIST-dependent genes, in CD11c(+) atypical memory B cells (ABCs). XIST inactivation with TLR7 agonism suffices to promote isotype-switched ABCs. These results indicate cell-type-specific diversification and function for lncRNA-protein complexes and suggest expanded roles for XIST in sex-differences in biology and medicine. |*COVID-19/genetics/immunology[MESH] |*Lupus Erythematosus, Systemic/genetics/immunology[MESH] |*X Chromosome Inactivation[MESH] |B-Lymphocytes/*immunology[MESH] |Cell Line[MESH] |DNA Methylation[MESH] |Female[MESH] |Gene Silencing[MESH] |Humans[MESH] |RNA, Long Noncoding/*physiology[MESH]B cell-specific XIST complex enforces X-inactivation and restrains aty(epmc).pdf DeepDyve Pubget Overpricing