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10.1371/journal.pone.0248553 http://scihub22266oqcxt.onion/10.1371/journal.pone.0248553 33735271!7971693!33735271     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (3): e0248553 Nephropedia Template TP {{tp|p=33735271|t=2021. A comprehensive SARS-CoV-2 genomic analysis identifies potential targets for drug repurposing |pdf=|usr=}}{{33735271}} gab.com Text A comprehensive SARS-CoV-2 genomic analysis identifies potential targets for drug repurposing JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33735271 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is a novel human coronavirus strain (HCoV) was initially reported in December 2019 in Wuhan City, China. This acute infection caused pneumonia-like symptoms and other respiratory tract illness. Its higher transmission and infection rate has successfully enabled it to have a global spread over a matter of small time. One of the major concerns involving the SARS-COV-2 is the mutation rate, which enhances the virus evolution and genome variability, thereby making the design of therapeutics difficult. In this study, we identified the most common haplotypes from the haplotype network. The conserved genes and population level variants were analysed. Non-Structural Protein 10 (NSP10), Nucleoprotein, Papain-like protease (Plpro or NSP3) and 3-Chymotrypsin like protease (3CLpro or NSP5), which were conserved at the highest threshold, were used as drug targets for molecular dynamics simulations. Darifenacin, Nebivolol, Bictegravir, Alvimopan and Irbesartan are among the potential drugs, which are suggested for further pre-clinical and clinical trials. This particular study provides a comprehensive targeting of the conserved genes. We also identified the mutation frequencies across the viral genome. Twit Text FOAVip A comprehensive SARS-CoV-2 genomic analysis identifies potential targets for drug repurposing ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33735271 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33735271 #FOAvip English Wikipedia <ref>{{Cite pmid|33735271}}</ref> A comprehensive SARS-CoV-2 genomic analysis identifies potential targets for drug repurposing #MMPMID33735271 Anand NM; Liya DH; Pradhan AK; Tayal N; Bansal A; Donakonda S; Jainarayanan AK PLoS One 2021[]; 16 (3): e0248553 PMID33735271show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is a novel human coronavirus strain (HCoV) was initially reported in December 2019 in Wuhan City, China. This acute infection caused pneumonia-like symptoms and other respiratory tract illness. Its higher transmission and infection rate has successfully enabled it to have a global spread over a matter of small time. One of the major concerns involving the SARS-COV-2 is the mutation rate, which enhances the virus evolution and genome variability, thereby making the design of therapeutics difficult. In this study, we identified the most common haplotypes from the haplotype network. The conserved genes and population level variants were analysed. Non-Structural Protein 10 (NSP10), Nucleoprotein, Papain-like protease (Plpro or NSP3) and 3-Chymotrypsin like protease (3CLpro or NSP5), which were conserved at the highest threshold, were used as drug targets for molecular dynamics simulations. Darifenacin, Nebivolol, Bictegravir, Alvimopan and Irbesartan are among the potential drugs, which are suggested for further pre-clinical and clinical trials. This particular study provides a comprehensive targeting of the conserved genes. We also identified the mutation frequencies across the viral genome. |*COVID-19 Drug Treatment[MESH] |COVID-19/*virology[MESH] |Drug Discovery/methods[MESH] |Drug Repositioning/*methods[MESH] |Genome, Viral[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Molecular Dynamics Simulation[MESH] |Mutation Rate[MESH] |SARS-CoV-2/drug effects/*genetics/metabolism[MESH]A comprehensive SARS-CoV-2 genomic analysis identifies potential targe(epmc).pdf DeepDyve Pubget Overpricing