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10.1021/acsnano.0c06836

http://scihub22266oqcxt.onion/10.1021/acsnano.0c06836
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33734675!ä!33734675

suck abstract from ncbi


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pmid33734675      ACS+Nano 2021 ; 15 (4): 6340-6351
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  • Membrane Nanoparticles Derived from ACE2-Rich Cells Block SARS-CoV-2 Infection #MMPMID33734675
  • Wang C; Wang S; Chen Y; Zhao J; Han S; Zhao G; Kang J; Liu Y; Wang L; Wang X; Xu Y; Wang S; Huang Y; Wang J; Zhao J
  • ACS Nano 2021[Apr]; 15 (4): 6340-6351 PMID33734675show ga
  • The ongoing COVID-19 pandemic worldwide necessitates the development of therapeutics against SARS-CoV-2. ACE2 is the main receptor of SARS-CoV-2 S1 and mediates viral entry into host cells. Herein, membrane nanoparticles (NPs) prepared from ACE2-rich cells were discovered to have potent capacity to block SARS-CoV-2 infection. The membranes of human embryonic kidney-239T cells highly expressing ACE2 were applied to prepare NPs using an extrusion method. The nanomaterials, termed ACE2-NPs, contained 265.1 ng mg(-1) ACE2 on the surface and acted as baits to trap S1 in a dose-dependent manner, resulting in reduced recruitment of the viral ligand to HK-2 human renal tubular epithelial cells. Aside from affecting receptor recongnition, S1 translocated to the cytoplasm and induced apoptosis by reducing optic atrophy 1 expression and increasing cytochrome c release, which was also inhibited by ACE2-NPs. Further investigations revealed that ACE2-NPs efficiently suppressed SARS-CoV-2 S pseudovirions entry into host cells and blocked viral infection in vitro and in vivo. This study characterizes easy-to-produce memrbane nanoantagonists of SARS-CoV-2 that enrich the existing antiviral arsenal and provide possibilities for COVID-19 treatment.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Nanoparticles[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A[MESH]
  • |SARS-CoV-2[MESH]


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