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10.1111/jcmm.16465 http://scihub22266oqcxt.onion/10.1111/jcmm.16465 33733611!8107092!33733611     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2021 ; 25 (10): 4870-4876 Nephropedia Template TP {{tp|p=33733611|t=2021. Med1 controls CD8 T cell maintenance through IL-7R-mediated cell survival signalling |pdf=|usr=}}{{33733611}} gab.com Text Med1 controls CD8 T cell maintenance through IL-7R-mediated cell survival signalling JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33733611 #FOAvip Under steady-state conditions, the pool size of peripheral CD8(+) T cells is maintained through turnover and survival. Beyond TCR and IL-7R signals, the underlying mechanisms are less well understood. In the present study, we found a significant reduction of CD8(+) T cell proportion in spleens but not in thymi of mice with T cell-specific deletion of Mediator Subunit 1 (Med1). A competitive transfer of wild-type (WT) and Med1-deficient CD8(+) T cells reproduced the phenotype in the same recipients and confirmed intrinsic role of Med1. Furthermore, we observed a comparable degree of migration and proliferation but a significant increase of cell death in Med1-deficient CD8(+) T cells compared with WT counterparts. Finally, Med1-deficient CD8(+) T cells exhibited a decreased expression of interleukin-7 receptor alpha (IL-7Ralpha), down-regulation of phosphorylated-STAT5 (pSTAT5) and Bim up-regulation. Collectively, our study reveals a novel role of Med1 in the maintenance of CD8(+) T cells through IL-7Ralpha/STAT5 pathway-mediated cell survival. Twit Text FOAVip Med1 controls CD8 T cell maintenance through IL-7R-mediated cell survival signalling ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33733611 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33733611 #FOAvip English Wikipedia <ref>{{Cite pmid|33733611}}</ref> Med1 controls CD8 T cell maintenance through IL-7R-mediated cell survival signalling #MMPMID33733611 Lei L; Yang X; Su Y; Zheng H; Liu J; Liu H; Zou Y; Jiao A; Wang X; Zhang C; Zhang X; Zhang J; Zhang D; Zhou X; Shi L; Liu E; Bai L; Sun C; Zhang B J Cell Mol Med 2021[May]; 25 (10): 4870-4876 PMID33733611show ga Under steady-state conditions, the pool size of peripheral CD8(+) T cells is maintained through turnover and survival. Beyond TCR and IL-7R signals, the underlying mechanisms are less well understood. In the present study, we found a significant reduction of CD8(+) T cell proportion in spleens but not in thymi of mice with T cell-specific deletion of Mediator Subunit 1 (Med1). A competitive transfer of wild-type (WT) and Med1-deficient CD8(+) T cells reproduced the phenotype in the same recipients and confirmed intrinsic role of Med1. Furthermore, we observed a comparable degree of migration and proliferation but a significant increase of cell death in Med1-deficient CD8(+) T cells compared with WT counterparts. Finally, Med1-deficient CD8(+) T cells exhibited a decreased expression of interleukin-7 receptor alpha (IL-7Ralpha), down-regulation of phosphorylated-STAT5 (pSTAT5) and Bim up-regulation. Collectively, our study reveals a novel role of Med1 in the maintenance of CD8(+) T cells through IL-7Ralpha/STAT5 pathway-mediated cell survival. |*CD8-Positive T-Lymphocytes/cytology/immunology[MESH] |Animals[MESH] |Apoptosis[MESH] |Bone Marrow Cells[MESH] |Cell Proliferation[MESH] |Cell Survival[MESH] |Cells, Cultured[MESH] |Mediator Complex Subunit 1/genetics/*immunology[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Mice, Transgenic[MESH] |Receptors, Interleukin-7/*immunology[MESH] |Signal Transduction[MESH]Med1 controls CD8 T cell maintenance through IL-7R-mediated cell survi(epmc).pdf DeepDyve Pubget Overpricing