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10.3389/fmed.2021.639103 http://scihub22266oqcxt.onion/10.3389/fmed.2021.639103 33732720!7956987!33732720     free     free     free       Front+Med+(Lausanne) 2021 ; 8 (ä): 639103 Nephropedia Template TP {{tp|p=33732720|t=2021. Interleukin-18 in Inflammatory Kidney Disease |pdf=|usr=}}{{33732720}} gab.com Text Interleukin-18 in Inflammatory Kidney Disease JO: Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=33732720 #FOAvip Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is structurally similar to IL-1beta. IL-18 promotes the production of interferon gamma (IFN-gamma) and strongly induces a Th1 response. IL-18 drives the same myeloid differentiation factor 88 (MyD88)/nuclear factor kappa B (NF-kappaB) signaling pathway as IL-1beta. In physiological conditions, IL-18 is regulated by the endogenous inhibitor IL-18 binding protein (IL-18BP), and the activity of IL-18 is balanced. It is reported that in several inflammatory diseases, the IL-18 activity is unbalanced, and IL-18 neutralization by IL-18BP is insufficient. IL-18 acts synergistically with IL-12 to induce the production of IFN-gamma as a Th1 cytokine, and IL-18 acts alone to induce the production of Th2 cytokines such as IL-4 and IL-13. In addition, IL-18 alone enhances natural killer (NK) cell activity and FAS ligand expression. The biological and pathological roles of IL-18 have been studied in many diseases. Here we review the knowledge regarding IL-18 signaling and the role of IL-18 in inflammatory kidney diseases. Findings on renal injury in coronavirus disease 2019 (COVID-19) and its association with IL-18 will also be presented. Twit Text FOAVip Interleukin-18 in Inflammatory Kidney Disease ????Front Med (Lausanne) http://www.kidney.de/pget.php?&tw=1&pmid=33732720 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33732720 #FOAvip English Wikipedia <ref>{{Cite pmid|33732720}}</ref> Interleukin-18 in Inflammatory Kidney Disease #MMPMID33732720 Hirooka Y; Nozaki Y Front Med (Lausanne) 2021[]; 8 (ä): 639103 PMID33732720show ga Interleukin (IL)-18, a member of the IL-1 superfamily, is a pro-inflammatory cytokine that is structurally similar to IL-1beta. IL-18 promotes the production of interferon gamma (IFN-gamma) and strongly induces a Th1 response. IL-18 drives the same myeloid differentiation factor 88 (MyD88)/nuclear factor kappa B (NF-kappaB) signaling pathway as IL-1beta. In physiological conditions, IL-18 is regulated by the endogenous inhibitor IL-18 binding protein (IL-18BP), and the activity of IL-18 is balanced. It is reported that in several inflammatory diseases, the IL-18 activity is unbalanced, and IL-18 neutralization by IL-18BP is insufficient. IL-18 acts synergistically with IL-12 to induce the production of IFN-gamma as a Th1 cytokine, and IL-18 acts alone to induce the production of Th2 cytokines such as IL-4 and IL-13. In addition, IL-18 alone enhances natural killer (NK) cell activity and FAS ligand expression. The biological and pathological roles of IL-18 have been studied in many diseases. Here we review the knowledge regarding IL-18 signaling and the role of IL-18 in inflammatory kidney diseases. Findings on renal injury in coronavirus disease 2019 (COVID-19) and its association with IL-18 will also be presented. äInterleukin-18 in Inflammatory Kidney Disease (epmc).pdf DeepDyve Pubget Overpricing