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10.3892/etm.2021.9750

http://scihub22266oqcxt.onion/10.3892/etm.2021.9750
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33732292!7903484!33732292
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suck abstract from ncbi


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pmid33732292      Exp+Ther+Med 2021 ; 21 (4): 319
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  • Immunoregulatory therapy strategies that target cytokine storms in patients with COVID-19 (Review) #MMPMID33732292
  • Wang X; He Z; Zhao X
  • Exp Ther Med 2021[Apr]; 21 (4): 319 PMID33732292show ga
  • A cytokine storm is an uncontrolled, excessive immune response that contributes to the pathogenesis of coronavirus disease 2019 (COVID-19). Viral infections lead to the loss of negative feedback in immune regulation and an abnormal elevation of the levels of multiple cytokines. In COVID-19, this causes diffuse damage to alveolar functions and may culminate in multiple organ dysfunction. Immunoregulatory therapies target the cytokine storms induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, and include monoclonal antibodies, recombinant granulocyte-macrophage colony stimulating factor, interferon, mesenchymal stem cell-based therapy, thymosin, immunoglobulins and blood purification therapies. These approaches may be effective in the alleviation of COVID-19 symptoms. In this review, cytokine storms caused by SARS-CoV-2 infections are evaluated and discussed, and advances in immunoregulatory therapy strategies for patients with COVID-19 are reviewed.
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