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10.1536/ihj.20-574

http://scihub22266oqcxt.onion/10.1536/ihj.20-574
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33731529!ä!33731529

suck abstract from ncbi


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pmid33731529      Int+Heart+J 2021 ; 62 (2): 274-281
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  • Clinical Profile and 30-Day Mortality of Invasively Managed Patients with Suspected Acute Coronary Syndrome During the COVID-19 Outbreak #MMPMID33731529
  • Salinas P; Travieso A; Vergara-Uzcategui C; Tirado-Conte G; Macaya F; Mejia-Renteria H; Nombela-Franco L; Nunez-Gil IJ; Gonzalo N; Jimenez-Quevedo P; Perez-Vizcayno MJ; Escaned J; Fernandez-Ortiz A
  • Int Heart J 2021[Mar]; 62 (2): 274-281 PMID33731529show ga
  • The COVID-19 pandemic severely disrupted cardiovascular care during the spring of 2020 in Europe. Our study analyzed the clinical profile, COVID-19 impact, and 30-day prognosis of invasively managed patients with acute coronary syndrome (ACS) compared to a historical cohort.All invasively managed ACS patients from March 1st to April 30th, 2020 were compared to a cohort from the same timeframe of 2019 (n = 316). COVID-19 confirmed cases were defined by a positive SARS-CoV-2 polymerase chain reaction (PCR) test (CoV+). The primary outcome was all-cause 30-day mortality and multivariable predictors of this outcome.A 40.4% reduction in ACS patients was noted (198 cases in 2019 to 118 in 2020), and 11% of 2020 ACS patients were CoV+. Baseline characteristics were similar between groups. There were significantly more in-hospital patients with ACS (15.3% versus 6.1%, P = 0.007), and fewer patients were found to have a culprit lesion (58.5% versus 74.2%, P = 0.004) in 2020 compared to 2019. Thirty-day mortality in 2020 (7%) was not different from that in 2019 (4.2%), P = 0.294, but it was significantly higher in CoV+ patients (23.1%) compared to that in negative SARS-CoV-2 PCR test (CoV-) patients (5%), P = 0.047, in the 2020 group. In the multivariate analysis, CoV+ was an independent mortality predictor (OR = 9.8, 95% CI = 1.48-64.78), along with the left ventricular ejection fraction (LVEF) (OR = 0.91, 95% CI = 0.86-0.97), P = 0.0006.This study found increased 30-day mortality of invasively managed CoV+ ACS patients compared to that of CoV- patients during the 2020 COVID-19 spring outbreak. In the multivariable analysis, a SARS-CoV-2 positive test was independently associated with 30-day mortality. Further investigations of the underlying physiopathological relations between COVID-19 and ACS are warranted.
  • |*Disease Outbreaks[MESH]
  • |Acute Coronary Syndrome/diagnosis/*mortality/*therapy[MESH]
  • |Aged[MESH]
  • |COVID-19/diagnosis/*epidemiology/therapy[MESH]
  • |Cohort Studies[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Myocardial Revascularization[MESH]
  • |Percutaneous Coronary Intervention[MESH]
  • |Prognosis[MESH]
  • |Spain[MESH]
  • |Stroke Volume[MESH]


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