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10.4062/biomolther.2021.032

http://scihub22266oqcxt.onion/10.4062/biomolther.2021.032
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33731494!8094065!33731494
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suck abstract from ncbi

pmid33731494      Biomol+Ther+(Seoul) 2021 ; 29 (3): 268-272
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  • Antiviral Efficacy of Pralatrexate against SARS-CoV-2 #MMPMID33731494
  • Bae JY; Lee GE; Park H; Cho J; Kim J; Lee J; Kim K; Kim JI; Park MS
  • Biomol Ther (Seoul) 2021[May]; 29 (3): 268-272 PMID33731494show ga
  • Novel coronavirus (SARS-CoV-2) has caused more than 100 million confirmed cases of human infectious disease (COVID-19) since December 2019 to paralyze our global community. However, only limited access has been allowed to COVID-19 vaccines and antiviral treatment options. Here, we report the efficacy of the anticancer drug pralatrexate against SARS-CoV-2. In Vero and human lung epithelial Calu-3 cells, pralatrexate reduced viral RNA copies of SARS-CoV-2 without detectable cytotoxicity, and viral replication was successfully inhibited in a dose-dependent manner. In a time-to-addition assay, pralatrexate treatment at almost half a day after infection also exhibited inhibitory effects on the replication of SARS-CoV-2 in Calu-3 cells. Taken together, these results suggest the potential of pralatrexate as a drug repurposing COVID-19 remedy.
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