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10.1136/bmjresp-2020-000813

http://scihub22266oqcxt.onion/10.1136/bmjresp-2020-000813
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33731329!7976675!33731329
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suck abstract from ncbi


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pmid33731329      BMJ+Open+Respir+Res 2021 ; 8 (1): ä
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  • Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysis #MMPMID33731329
  • Cheng D; Calderwood C; Skyllberg E; Ainley A
  • BMJ Open Respir Res 2021[Mar]; 8 (1): ä PMID33731329show ga
  • BACKGROUND: Descriptions of clinical characteristics of patients hospitalised withCOVID-19, their clinical course and short-term inpatient and outpatient outcomes in deprived urban populations in the UK are still relatively sparse. We describe the epidemiology, clinical course, experience of non-invasive ventilation and intensive care, mortality and short-term sequelae of patients admitted to two large District General Hospitals across a large East London National Health Service Trust during the first wave of the pandemic. METHODS: A retrospective analysis was carried out on a cohort of 1946 patients with a clinical or laboratory diagnosis of COVID-19, including descriptive statistics and survival analysis. A more detailed analysis was undertaken of a subset of patients admitted across three respiratory units in the trust. RESULTS: Increasing age, male sex and Asian ethnicity were associated with worse outcomes. Increasing severity of chest X-ray abnormalities trended with mortality. Radiological changes persisted in over 50% of cases at early follow-up (6 weeks). Ongoing symptoms including hair loss, memory impairment, breathlessness, cough and fatigue were reported in 70% of survivors, with 39% of patients unable to return to work due to ongoing symptoms. CONCLUSIONS: Understanding the acute clinical features, course of illness and outcomes of COVID-19 will be crucial in understanding the effect of differences in risk, as well as the effectiveness of new interventions and vaccination between the successive waves of the pandemic.
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Alopecia/physiopathology[MESH]
  • |COVID-19/*complications/*epidemiology/mortality/physiopathology/therapy[MESH]
  • |Cohort Studies[MESH]
  • |Cough/physiopathology[MESH]
  • |Dyspnea/physiopathology[MESH]
  • |Ethnicity[MESH]
  • |Fatigue/physiopathology[MESH]
  • |Female[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Intensive Care Units/statistics & numerical data[MESH]
  • |London/epidemiology[MESH]
  • |Male[MESH]
  • |Memory Disorders/physiopathology[MESH]
  • |Middle Aged[MESH]
  • |Multivariate Analysis[MESH]
  • |Noninvasive Ventilation/statistics & numerical data[MESH]
  • |Post-Acute COVID-19 Syndrome[MESH]
  • |Proportional Hazards Models[MESH]
  • |Retrospective Studies[MESH]
  • |Return to Work[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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