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10.1016/j.cell.2021.02.037 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.02.037 33730597!7901269!33730597     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (9): 2348-2361.e6 Nephropedia Template TP {{tp|p=33730597|t=2021. Evidence of escape of SARS-CoV-2 variant B 1 351 from natural and vaccine-induced sera |pdf=|usr=}}{{33730597}} gab.com Text Evidence of escape of SARS-CoV-2 variant B 1 351 from natural and vaccine-induced sera JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33730597 #FOAvip The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began when the first sequence was published, and this forms the basis for vaccines currently deployed globally. Independent lineages of SARS-CoV-2 have recently been reported: UK, B.1.1.7; South Africa, B.1.351; and Brazil, P.1. These variants have multiple changes in the immunodominant spike protein that facilitates viral cell entry via the angiotensin-converting enzyme-2 (ACE2) receptor. Mutations in the receptor recognition site on the spike are of great concern for their potential for immune escape. Here, we describe a structure-function analysis of B.1.351 using a large cohort of convalescent and vaccinee serum samples. The receptor-binding domain mutations provide tighter ACE2 binding and widespread escape from monoclonal antibody neutralization largely driven by E484K, although K417N and N501Y act together against some important antibody classes. In a number of cases, it would appear that convalescent and some vaccine serum offers limited protection against this variant. Twit Text FOAVip Evidence of escape of SARS-CoV-2 variant B 1 351 from natural and vaccine-induced sera ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33730597 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33730597 #FOAvip English Wikipedia <ref>{{Cite pmid|33730597}}</ref> Evidence of escape of SARS-CoV-2 variant B 1 351 from natural and vaccine-induced sera #MMPMID33730597 Zhou D; Dejnirattisai W; Supasa P; Liu C; Mentzer AJ; Ginn HM; Zhao Y; Duyvesteyn HME; Tuekprakhon A; Nutalai R; Wang B; Paesen GC; Lopez-Camacho C; Slon-Campos J; Hallis B; Coombes N; Bewley K; Charlton S; Walter TS; Skelly D; Lumley SF; Dold C; Levin R; Dong T; Pollard AJ; Knight JC; Crook D; Lambe T; Clutterbuck E; Bibi S; Flaxman A; Bittaye M; Belij-Rammerstorfer S; Gilbert S; James W; Carroll MW; Klenerman P; Barnes E; Dunachie SJ; Fry EE; Mongkolsapaya J; Ren J; Stuart DI; Screaton GR Cell 2021[Apr]; 184 (9): 2348-2361.e6 PMID33730597show ga The race to produce vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began when the first sequence was published, and this forms the basis for vaccines currently deployed globally. Independent lineages of SARS-CoV-2 have recently been reported: UK, B.1.1.7; South Africa, B.1.351; and Brazil, P.1. These variants have multiple changes in the immunodominant spike protein that facilitates viral cell entry via the angiotensin-converting enzyme-2 (ACE2) receptor. Mutations in the receptor recognition site on the spike are of great concern for their potential for immune escape. Here, we describe a structure-function analysis of B.1.351 using a large cohort of convalescent and vaccinee serum samples. The receptor-binding domain mutations provide tighter ACE2 binding and widespread escape from monoclonal antibody neutralization largely driven by E484K, although K417N and N501Y act together against some important antibody classes. In a number of cases, it would appear that convalescent and some vaccine serum offers limited protection against this variant. |Animals[MESH] |Antibodies, Monoclonal/immunology[MESH] |COVID-19 Serotherapy[MESH] |COVID-19 Vaccines/*blood/*immunology[MESH] |COVID-19/immunology/therapy/virology[MESH] |Chlorocebus aethiops[MESH] |Clinical Trials as Topic[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Models, Molecular[MESH] |Mutation/genetics[MESH] |Neutralization Tests[MESH] |Protein Binding[MESH] |SARS-CoV-2/chemistry/genetics/*immunology[MESH]Evidence of escape of SARS-CoV-2 variant B 1 351 from natural and vacc(epmc).pdf DeepDyve Pubget Overpricing