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10.1016/j.celrep.2021.108852 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.108852 33730580!7962998!33730580     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 34 (11): 108852 Nephropedia Template TP {{tp|p=33730580|t=2021. Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies |pdf=|usr=}}{{33730580}} gab.com Text Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33730580 #FOAvip As the global COVID-19 pandemic progresses, it is paramount to gain knowledge on adaptive immunity to SARS-CoV-2 in children to define immune correlates of protection upon immunization or infection. We analyzed anti-SARS-CoV-2 antibodies and their neutralizing activity (PRNT) in 66 COVID-19-infected children at 7 (+/-2) days after symptom onset. Individuals with specific humoral responses presented faster virus clearance and lower viral load associated with a reduced in vitro infectivity. We demonstrated that the frequencies of SARS-CoV-2-specific CD4(+)CD40L(+) T cells and Spike-specific B cells were associated with the anti-SARS-CoV-2 antibodies and the magnitude of neutralizing activity. The plasma proteome confirmed the association between cellular and humoral SARS-CoV-2 immunity, and PRNT(+) patients show higher viral signal transduction molecules (SLAMF1, CD244, CLEC4G). This work sheds lights on cellular and humoral anti-SARS-CoV-2 responses in children, which may drive future vaccination trial endpoints and quarantine measures policies. Twit Text FOAVip Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33730580 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33730580 #FOAvip English Wikipedia <ref>{{Cite pmid|33730580}}</ref> Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies #MMPMID33730580 Cotugno N; Ruggiero A; Bonfante F; Petrara MR; Zicari S; Pascucci GR; Zangari P; De Ioris MA; Santilli V; Manno EC; Amodio D; Bortolami A; Pagliari M; Concato C; Linardos G; Campana A; Dona D; Giaquinto C; Brodin P; Rossi P; De Rossi A; Palma P Cell Rep 2021[Mar]; 34 (11): 108852 PMID33730580show ga As the global COVID-19 pandemic progresses, it is paramount to gain knowledge on adaptive immunity to SARS-CoV-2 in children to define immune correlates of protection upon immunization or infection. We analyzed anti-SARS-CoV-2 antibodies and their neutralizing activity (PRNT) in 66 COVID-19-infected children at 7 (+/-2) days after symptom onset. Individuals with specific humoral responses presented faster virus clearance and lower viral load associated with a reduced in vitro infectivity. We demonstrated that the frequencies of SARS-CoV-2-specific CD4(+)CD40L(+) T cells and Spike-specific B cells were associated with the anti-SARS-CoV-2 antibodies and the magnitude of neutralizing activity. The plasma proteome confirmed the association between cellular and humoral SARS-CoV-2 immunity, and PRNT(+) patients show higher viral signal transduction molecules (SLAMF1, CD244, CLEC4G). This work sheds lights on cellular and humoral anti-SARS-CoV-2 responses in children, which may drive future vaccination trial endpoints and quarantine measures policies. |Adaptive Immunity/immunology[MESH] |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/*immunology[MESH] |B-Lymphocytes/immunology[MESH] |CD4-Positive T-Lymphocytes/immunology[MESH] |COVID-19/*immunology/virology[MESH] |Child[MESH] |Humans[MESH] |Immunity, Humoral/immunology[MESH] |Proteome/immunology[MESH] |SARS-CoV-2/immunology[MESH] |Signal Transduction/immunology[MESH]Virological and immunological features of SARS-CoV-2-infected children(epmc).pdf DeepDyve Pubget Overpricing