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10.1016/j.celrep.2021.108872 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.108872 33730572!7962955!33730572     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 34 (11): 108872 Nephropedia Template TP {{tp|p=33730572|t=2021. Translational adaptation of human viruses to the tissues they infect |pdf=|usr=}}{{33730572}} gab.com Text Translational adaptation of human viruses to the tissues they infect JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33730572 #FOAvip Viruses need to hijack the translational machinery of the host cell for a productive infection to happen. However, given the dynamic landscape of tRNA pools among tissues, it is unclear whether different viruses infecting different tissues have adapted their codon usage toward their tropism. Here, we collect the coding sequences of 502 human-infecting viruses and determine that tropism explains changes in codon usage. Using the tRNA abundances across 23 human tissues from The Cancer Genome Atlas (TCGA), we build an in silico model of translational efficiency that validates the correspondence of the viral codon usage with the translational machinery of their tropism. For instance, we detect that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is specifically adapted to the upper respiratory tract and alveoli. Furthermore, this correspondence is specifically defined in early viral proteins. The observed tissue-specific translational efficiency could be useful for the development of antiviral therapies and vaccines. Twit Text FOAVip Translational adaptation of human viruses to the tissues they infect ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33730572 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33730572 #FOAvip English Wikipedia <ref>{{Cite pmid|33730572}}</ref> Translational adaptation of human viruses to the tissues they infect #MMPMID33730572 Hernandez-Alias X; Benisty H; Schaefer MH; Serrano L Cell Rep 2021[Mar]; 34 (11): 108872 PMID33730572show ga Viruses need to hijack the translational machinery of the host cell for a productive infection to happen. However, given the dynamic landscape of tRNA pools among tissues, it is unclear whether different viruses infecting different tissues have adapted their codon usage toward their tropism. Here, we collect the coding sequences of 502 human-infecting viruses and determine that tropism explains changes in codon usage. Using the tRNA abundances across 23 human tissues from The Cancer Genome Atlas (TCGA), we build an in silico model of translational efficiency that validates the correspondence of the viral codon usage with the translational machinery of their tropism. For instance, we detect that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is specifically adapted to the upper respiratory tract and alveoli. Furthermore, this correspondence is specifically defined in early viral proteins. The observed tissue-specific translational efficiency could be useful for the development of antiviral therapies and vaccines. |Cell Line[MESH] |Cell Line, Tumor[MESH] |Codon Usage/genetics[MESH] |Genes, Neoplasm/genetics[MESH] |HCT116 Cells[MESH] |HEK293 Cells[MESH] |HeLa Cells[MESH] |Hep G2 Cells[MESH] |Humans[MESH] |Protein Biosynthesis/*genetics[MESH] |Pulmonary Alveoli/virology[MESH] |RNA, Transfer/genetics[MESH] |Respiratory Tract Infections/virology[MESH] |Tropism/genetics[MESH] |Viral Proteins/genetics[MESH] |Virus Diseases/*genetics/virology[MESH]Translational adaptation of human viruses to the tissues they infect (epmc).pdf DeepDyve Pubget Overpricing