SARS-CoV-2 viral dynamics in non-human primates #MMPMID33730053
Goncalves A; Maisonnasse P; Donati F; Albert M; Behillil S; Contreras V; Naninck T; Marlin R; Solas C; Pizzorno A; Lemaitre J; Kahlaoui N; Terrier O; Ho Tsong Fang R; Enouf V; Dereuddre-Bosquet N; Brisebarre A; Touret F; Chapon C; Hoen B; Lina B; Rosa Calatrava M; de Lamballerie X; Mentre F; Le Grand R; van der Werf S; Guedj J
PLoS Comput Biol 2021[Mar]; 17 (3): e1008785 PMID33730053show ga
Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large burst size (>104 virus) and a within-host reproductive basic number of approximately 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly lost with a half-life of 9 hours, with no significant association between cytokine elevation and clearance, leading to a median time to viral clearance of 10 days, consistent with observations in mild human infections. Given these parameter estimates, we predict that a prophylactic treatment blocking 90% of viral production or viral infection could prevent viral growth. In conclusion, our results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.
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PLoS+Comput+Biol 2021 ; 17 (3): e1008785
