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10.1371/journal.pone.0246981 http://scihub22266oqcxt.onion/10.1371/journal.pone.0246981 33730017!7968707!33730017     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33730017&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (3): e0246981 Nephropedia Template TP {{tp|p=33730017|t=2021. Structural analysis of viral ExoN domains reveals polyphyletic hijacking events |pdf=|usr=}}{{33730017}} gab.com Text Structural analysis of viral ExoN domains reveals polyphyletic hijacking events JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33730017 #FOAvip Nidoviruses and arenaviruses are the only known RNA viruses encoding a 3'-5' exonuclease domain (ExoN). The proofreading activity of the ExoN domain has played a key role in the growth of nidoviral genomes, while in arenaviruses this domain partakes in the suppression of the host innate immune signaling. Sequence and structural homology analyses suggest that these proteins have been hijacked from cellular hosts many times. Analysis of the available nidoviral ExoN sequences reveals a high conservation level comparable to that of the viral RNA-dependent RNA polymerases (RdRp), which are the most conserved viral proteins. Two highly preserved zinc fingers are present in all nidoviral exonucleases, while in the arenaviral protein only one zinc finger can be identified. This is in sharp contrast with the reported lack of zinc fingers in cellular ExoNs, and opens the possibility of therapeutic strategies in the struggle against COVID-19. Twit Text FOAVip Structural analysis of viral ExoN domains reveals polyphyletic hijacking events ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33730017 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33730017 #FOAvip English Wikipedia <ref>{{Cite pmid|33730017}}</ref> Structural analysis of viral ExoN domains reveals polyphyletic hijacking events #MMPMID33730017 Cruz-Gonzalez A; Munoz-Velasco I; Cottom-Salas W; Becerra A; Campillo-Balderas JA; Hernandez-Morales R; Vazquez-Salazar A; Jacome R; Lazcano A PLoS One 2021[]; 16 (3): e0246981 PMID33730017show ga Nidoviruses and arenaviruses are the only known RNA viruses encoding a 3'-5' exonuclease domain (ExoN). The proofreading activity of the ExoN domain has played a key role in the growth of nidoviral genomes, while in arenaviruses this domain partakes in the suppression of the host innate immune signaling. Sequence and structural homology analyses suggest that these proteins have been hijacked from cellular hosts many times. Analysis of the available nidoviral ExoN sequences reveals a high conservation level comparable to that of the viral RNA-dependent RNA polymerases (RdRp), which are the most conserved viral proteins. Two highly preserved zinc fingers are present in all nidoviral exonucleases, while in the arenaviral protein only one zinc finger can be identified. This is in sharp contrast with the reported lack of zinc fingers in cellular ExoNs, and opens the possibility of therapeutic strategies in the struggle against COVID-19. |Amino Acid Sequence[MESH] |Arenavirus/genetics[MESH] |COVID-19/virology[MESH] |Exonucleases/*genetics[MESH] |Humans[MESH] |Immunity, Innate/genetics[MESH] |Nidovirales/genetics[MESH] |Protein Domains/*genetics[MESH] |RNA Viruses/genetics[MESH] |RNA, Viral/*genetics[MESH] |RNA-Dependent RNA Polymerase/genetics[MESH] |SARS-CoV-2/genetics[MESH] |Viral Proteins/*genetics[MESH]Structural analysis of viral ExoN domains reveals polyphyletic hijacki(epmc).pdf DeepDyve Pubget Overpricing