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10.1371/journal.pcbi.1008805 http://scihub22266oqcxt.onion/10.1371/journal.pcbi.1008805 33730015!8007013!33730015     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Comput+Biol 2021 ; 17 (3): e1008805 Nephropedia Template TP {{tp|p=33730015|t=2021. Gene variants of coagulation related proteins that interact with SARS-CoV-2 |pdf=|usr=}}{{33730015}} gab.com Text Gene variants of coagulation related proteins that interact with SARS-CoV-2 JO: PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=33730015 #FOAvip Thrombosis is a recognized complication of Coronavirus disease of 2019 (COVID-19) and is often associated with poor prognosis. There is a well-recognized link between coagulation and inflammation, however, the extent of thrombotic events associated with COVID-19 warrants further investigation. Poly(A) Binding Protein Cytoplasmic 4 (PABPC4), Serine/Cysteine Proteinase Inhibitor Clade G Member 1 (SERPING1) and Vitamin K epOxide Reductase Complex subunit 1 (VKORC1), which are all proteins linked to coagulation, have been shown to interact with SARS proteins. We computationally examined the interaction of these with SARS-CoV-2 proteins and, in the case of VKORC1, we describe its binding to ORF7a in detail. We examined the occurrence of variants of each of these proteins across populations and interrogated their potential contribution to COVID-19 severity. Potential mechanisms, by which some of these variants may contribute to disease, are proposed. Some of these variants are prevalent in minority groups that are disproportionally affected by severe COVID-19. Therefore, we are proposing that further investigation around these variants may lead to better understanding of disease pathogenesis in minority groups and more informed therapeutic approaches. Twit Text FOAVip Gene variants of coagulation related proteins that interact with SARS-CoV-2 ????PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=33730015 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33730015 #FOAvip English Wikipedia <ref>{{Cite pmid|33730015}}</ref> Gene variants of coagulation related proteins that interact with SARS-CoV-2 #MMPMID33730015 Holcomb D; Alexaki A; Hernandez N; Hunt R; Laurie K; Kames J; Hamasaki-Katagiri N; Komar AA; DiCuccio M; Kimchi-Sarfaty C PLoS Comput Biol 2021[Mar]; 17 (3): e1008805 PMID33730015show ga Thrombosis is a recognized complication of Coronavirus disease of 2019 (COVID-19) and is often associated with poor prognosis. There is a well-recognized link between coagulation and inflammation, however, the extent of thrombotic events associated with COVID-19 warrants further investigation. Poly(A) Binding Protein Cytoplasmic 4 (PABPC4), Serine/Cysteine Proteinase Inhibitor Clade G Member 1 (SERPING1) and Vitamin K epOxide Reductase Complex subunit 1 (VKORC1), which are all proteins linked to coagulation, have been shown to interact with SARS proteins. We computationally examined the interaction of these with SARS-CoV-2 proteins and, in the case of VKORC1, we describe its binding to ORF7a in detail. We examined the occurrence of variants of each of these proteins across populations and interrogated their potential contribution to COVID-19 severity. Potential mechanisms, by which some of these variants may contribute to disease, are proposed. Some of these variants are prevalent in minority groups that are disproportionally affected by severe COVID-19. Therefore, we are proposing that further investigation around these variants may lead to better understanding of disease pathogenesis in minority groups and more informed therapeutic approaches. |*Blood Coagulation[MESH] |Anticoagulants/administration & dosage[MESH] |Blood Proteins/*genetics/metabolism[MESH] |COVID-19/*metabolism/physiopathology/virology[MESH] |Complement C1 Inhibitor Protein/*genetics/metabolism[MESH] |Genome-Wide Association Study[MESH] |Humans[MESH] |Models, Molecular[MESH] |Mutation[MESH] |Poly(A)-Binding Proteins/*genetics/metabolism[MESH] |Protein Binding[MESH] |SARS-CoV-2/genetics/*metabolism[MESH] |Severity of Illness Index[MESH] |Viral Proteins/metabolism[MESH] |Vitamin K Epoxide Reductases/*genetics/metabolism[MESH]Gene variants of coagulation related proteins that interact with SARS-(epmc).pdf DeepDyve Pubget Overpricing