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10.1590/1678-4685-GMB-2020-0199 http://scihub22266oqcxt.onion/10.1590/1678-4685-GMB-2020-0199 33729332!7982787!33729332     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33729332&cmd=llinks): Failed to open stream: HTTP request failed! 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MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 |pdf=|usr=}}{{33729332}} gab.com Text MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 JO: Genet Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=33729332 #FOAvip Components of the complement system and atypical parameters of coagulation were reported in COVID-19 patients, as well as the exacerbation of the inflammation and coagulation activity. Mannose binding lectin (MBL)- associated serine proteases (MASPs) play an important role in viral recognition and subsequent activation of the lectin pathway of the complement system and blood coagulation, connecting both processes. Genetic variants of MASP1 and MASP2 genes are further associated with different levels and functional efficiency of their encoded proteins, modulating susceptibility and severity to diseases. Our review highlights the possible role of MASPs in SARS-COV-2 binding and activation of the lectin pathway and blood coagulation cascades, as well as their associations with comorbidities of COVID-19. MASP-1 and/or MASP-2 present an increased expression in patients with COVID-19 risk factors: diabetes, arterial hypertension and cardiovascular disease, chronic kidney disease, chronic obstructive pulmonary disease, and cerebrovascular disease. Based also on the positive results of COVID-19 patients with anti-MASP-2 antibody, we propose the use of MASPs as a possible biomarker of the progression of COVID-19 and the investigation of new treatment strategies taking into consideration the dual role of MASPs, including MASP inhibitors as promising therapeutic targets against COVID-19. Twit Text FOAVip MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 ????Genet Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=33729332 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33729332 #FOAvip English Wikipedia <ref>{{Cite pmid|33729332}}</ref> MASPs at the crossroad between the complement and the coagulation cascades - the case for COVID-19 #MMPMID33729332 Bumiller-Bini V; de Freitas Oliveira-Tore C; Carvalho TM; Kretzschmar GC; Goncalves LB; Alencar NM; Gasparetto Filho MA; Beltrame MH; Winter Boldt AB Genet Mol Biol 2021[]; 44 (1 Suppl 1): e20200199 PMID33729332show ga Components of the complement system and atypical parameters of coagulation were reported in COVID-19 patients, as well as the exacerbation of the inflammation and coagulation activity. Mannose binding lectin (MBL)- associated serine proteases (MASPs) play an important role in viral recognition and subsequent activation of the lectin pathway of the complement system and blood coagulation, connecting both processes. Genetic variants of MASP1 and MASP2 genes are further associated with different levels and functional efficiency of their encoded proteins, modulating susceptibility and severity to diseases. Our review highlights the possible role of MASPs in SARS-COV-2 binding and activation of the lectin pathway and blood coagulation cascades, as well as their associations with comorbidities of COVID-19. MASP-1 and/or MASP-2 present an increased expression in patients with COVID-19 risk factors: diabetes, arterial hypertension and cardiovascular disease, chronic kidney disease, chronic obstructive pulmonary disease, and cerebrovascular disease. Based also on the positive results of COVID-19 patients with anti-MASP-2 antibody, we propose the use of MASPs as a possible biomarker of the progression of COVID-19 and the investigation of new treatment strategies taking into consideration the dual role of MASPs, including MASP inhibitors as promising therapeutic targets against COVID-19. äMASPs at the crossroad between the complement and the coagulation casc(epmc).pdf DeepDyve Pubget Overpricing