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10.1038/s41379-021-00790-1 http://scihub22266oqcxt.onion/10.1038/s41379-021-00790-1 33727695!9813560!33727695     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mod+Pathol 2021 ; 34 (7): 1345-1357 Nephropedia Template TP {{tp|p=33727695|t=2021. Factors associated with myocardial SARS-CoV-2 infection, myocarditis, and cardiac inflammation in patients with COVID-19 |pdf=|usr=}}{{33727695}} gab.com Text Factors associated with myocardial SARS-CoV-2 infection, myocarditis, and cardiac inflammation in patients with COVID-19 JO: Mod Pathol http://www.kidney.de/pget.php?&tw=1&pmid=33727695 #FOAvip COVID-19 has been associated with cardiac injury and dysfunction. While both myocardial inflammatory cell infiltration and myocarditis with myocyte injury have been reported in patients with fatal COVID-19, clinical-pathologic correlations remain limited. The objective was to determine the relationships between cardiac pathological changes in patients dying from COVID-19 and cardiac infection by SARS-CoV-2, laboratory measurements, clinical features, and treatments. In a retrospective study, 41 consecutive autopsies of patients with fatal COVID-19 were analyzed for the associations between cardiac inflammation, myocarditis, cardiac infection by SARS-CoV-2, clinical features, laboratory measurements, and treatments. Cardiac infection was assessed by in situ hybridization and NanoString transcriptomic profiling. Cardiac infection by SARS-CoV-2 was present in 30/41 cases: virus(+) with myocarditis (n = 4), virus(+) without myocarditis (n = 26), and virus(-) without myocarditis (n = 11). In the cases with cardiac infection, SARS-CoV-2(+) cells in the myocardium were rare, with a median density of 1 cell/cm(2). Virus(+) cases showed higher densities of myocardial CD68(+) macrophages and CD3(+) lymphocytes, as well as more electrocardiographic changes (23/27 vs 4/10; P = 0.01). Myocarditis was more prevalent with IL-6 blockade than with nonbiologic immunosuppression, primarily glucocorticoids (2/3 vs 0/14; P = 0.02). Overall, SARS-CoV-2 cardiac infection was less prevalent in patients treated with nonbiologic immunosuppression (7/14 vs 21/24; P = 0.02). Myocardial macrophage and lymphocyte densities overall were positively correlated with the duration of symptoms but not with underlying comorbidities. In summary, cardiac infection with SARS-CoV-2 is common among patients dying from COVID-19 but often with only rare infected cells. Cardiac infection by SARS-CoV-2 is associated with more cardiac inflammation and electrocardiographic changes. Nonbiologic immunosuppression is associated with lower incidences of myocarditis and cardiac infection by SARS-CoV-2. Twit Text FOAVip Factors associated with myocardial SARS-CoV-2 infection, myocarditis, and cardiac inflammation in patients with COVID-19 ????Mod Pathol http://www.kidney.de/pget.php?&tw=1&pmid=33727695 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33727695 #FOAvip English Wikipedia <ref>{{Cite pmid|33727695}}</ref> Factors associated with myocardial SARS-CoV-2 infection, myocarditis, and cardiac inflammation in patients with COVID-19 #MMPMID33727695 Bearse M; Hung YP; Krauson AJ; Bonanno L; Boyraz B; Harris CK; Helland TL; Hilburn CF; Hutchison B; Jobbagy S; Marshall MS; Shepherd DJ; Villalba JA; Delfino I; Mendez-Pena J; Chebib I; Newton-Cheh C; Stone JR Mod Pathol 2021[Jul]; 34 (7): 1345-1357 PMID33727695show ga COVID-19 has been associated with cardiac injury and dysfunction. While both myocardial inflammatory cell infiltration and myocarditis with myocyte injury have been reported in patients with fatal COVID-19, clinical-pathologic correlations remain limited. The objective was to determine the relationships between cardiac pathological changes in patients dying from COVID-19 and cardiac infection by SARS-CoV-2, laboratory measurements, clinical features, and treatments. In a retrospective study, 41 consecutive autopsies of patients with fatal COVID-19 were analyzed for the associations between cardiac inflammation, myocarditis, cardiac infection by SARS-CoV-2, clinical features, laboratory measurements, and treatments. Cardiac infection was assessed by in situ hybridization and NanoString transcriptomic profiling. Cardiac infection by SARS-CoV-2 was present in 30/41 cases: virus(+) with myocarditis (n = 4), virus(+) without myocarditis (n = 26), and virus(-) without myocarditis (n = 11). In the cases with cardiac infection, SARS-CoV-2(+) cells in the myocardium were rare, with a median density of 1 cell/cm(2). Virus(+) cases showed higher densities of myocardial CD68(+) macrophages and CD3(+) lymphocytes, as well as more electrocardiographic changes (23/27 vs 4/10; P = 0.01). Myocarditis was more prevalent with IL-6 blockade than with nonbiologic immunosuppression, primarily glucocorticoids (2/3 vs 0/14; P = 0.02). Overall, SARS-CoV-2 cardiac infection was less prevalent in patients treated with nonbiologic immunosuppression (7/14 vs 21/24; P = 0.02). Myocardial macrophage and lymphocyte densities overall were positively correlated with the duration of symptoms but not with underlying comorbidities. In summary, cardiac infection with SARS-CoV-2 is common among patients dying from COVID-19 but often with only rare infected cells. Cardiac infection by SARS-CoV-2 is associated with more cardiac inflammation and electrocardiographic changes. Nonbiologic immunosuppression is associated with lower incidences of myocarditis and cardiac infection by SARS-CoV-2. |Aged[MESH] |Anticoagulants/therapeutic use[MESH] |Autopsy[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/blood/*pathology[MESH] |Echocardiography[MESH] |Electrocardiography[MESH] |Female[MESH] |Humans[MESH] |Immunosuppressive Agents/therapeutic use[MESH] |Male[MESH] |Myocarditis/pathology/virology[MESH] |Myocardium/pathology[MESH] |Retrospective Studies[MESH]Factors associated with myocardial SARS-CoV-2 infection, myocarditis, (epmc).pdf DeepDyve Pubget Overpricing